Home History
| England EFL Trophy | 2022/10/04 18:00 | Milton Keynes Dons v West Ham U21 | L | 2-0 |
| England Premier League 2 | 2022/10/01 13:00 | West Ham U21 v Crystal Palace U21 | L | 0-1 |
| England Premier League 2 | 2022/09/16 18:00 | Man Utd U21 v West Ham U21 | D | 1-1 |
| England Premier League 2 | 2022/09/03 13:00 | Man City U21 v West Ham U21 | L | 4-1 |
| England EFL Trophy | 2022/08/30 18:00 | Walsall v West Ham U21 | W | 0-1 |
| England Premier League 2 | 2022/08/27 11:00 | West Ham U21 v Everton U21 | L | 1-2 |
| England Premier League 2 | 2022/08/19 18:00 | Leicester U21 v West Ham U21 | L | 3-1 |
| England Premier League 2 | 2022/08/12 18:00 | West Ham U21 v Arsenal U21 | L | 2-3 |
Away History
| England EFL Trophy | 2022/10/04 18:45 | Oxford Utd v Chelsea U21 | W | 1-2 |
| England Premier League 2 | 2022/10/01 11:00 | Chelsea U21 v Leicester U21 | D | 2-2 |
| England Premier League 2 | 2022/09/17 13:00 | Crystal Palace U21 v Chelsea U21 | D | 3-3 |
| England Premier League 2 | 2022/09/03 11:00 | Everton U21 v Chelsea U21 | W | 0-2 |
| England EFL Trophy | 2022/08/31 18:45 | Sutton Utd v Chelsea U21 | L | 1-0 |
| England Premier League 2 | 2022/08/26 18:00 | Chelsea U21 v Man City U21 | D | 2-2 |
| England Premier League 2 | 2022/08/20 13:00 | Arsenal U21 v Chelsea U21 | L | 4-1 |
| England Premier League 2 | 2022/08/15 18:00 | Chelsea U21 v Fulham U21 | L | 0-3 |