Stadium: Five Star Stadium Round: 1
Home Manager: Drew Cronic Away Manager: Rob Tenyer
| NCAAF | 2021/11/20 19:00 | Morehead State v Valparaiso | W | 51-38 |
| NCAAF | 2021/11/13 18:00 | Stetson Hatters v Morehead State | W | 35-36 |
| NCAAF | 2021/11/06 20:00 | Morehead State v San Diego | L | 3-10 |
| NCAAF | 2021/10/30 18:00 | Davidson Wildcats v Morehead State | L | 29-22 |
| NCAAF | 2021/10/23 16:00 | Morehead State v Marist | W | 27-24 |
| NCAAF | 2021/10/16 19:00 | Butler v Morehead State | W | 8-31 |
| NCAAF | 2021/10/09 17:00 | Morehead State v Presbyterian | W | 38-30 |
| NCAAF | 2021/10/02 18:00 | Dayton v Morehead State | W | 38-45 |
| NCAAF | 2021/11/20 18:00 | Mercer v East Tennessee State | L | 35-38 |
| NCAAF | 2021/11/13 20:00 | Tennessee Chattanooga v Mercer | W | 6-10 |
| NCAAF | 2021/10/30 18:00 | Mercer v The Citadel | W | 34-7 |
| NCAAF | 2021/10/23 22:00 | Wofford v Mercer | W | 14-45 |
| NCAAF | 2021/10/16 20:00 | VMI v Mercer | L | 45-7 |
| NCAAF | 2021/10/09 19:30 | Mercer v Western Carolina | W | 34-24 |
| NCAAF | 2021/10/02 22:00 | Samford v Mercer | W | 42-45 |
| NCAAF | 2021/09/25 18:00 | Mercer v Furman | W | 24-3 |