SE Missouri State 34-31 Southern Illinois 2022-09-10 23:00
Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Tom Matukewicz
Head to Head
| NCAAF | 2021/09/02 23:30 | SO Illinois v SE Missouri St | L | 47-21 |
| NCAAF | 2020/10/30 23:00 | SE Missouri St v SO Illinois | L | 17-20 |
| NCAAF | 2019/08/29 23:30 | SO Illinois v SE Missouri St | W | 26-44 |
| NCAAF | 2018/09/15 23:00 | SE Missouri St v SO Illinois | W | 48-44 |
| NCAAF | 2017/09/16 23:00 | SE Missouri St v SO Illinois | L | 17-35 |
Home History
| NCAAF | 2022/09/03 18:00 | SE Missouri St v Iowa State | L | 10-42 |
| NCAAF | 2021/11/20 19:00 | Tennessee Martin v SE Missouri St | W | 14-31 |
| NCAAF | 2021/11/13 19:00 | SE Missouri St v Murray State | L | 10-28 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | W | 15-38 |
| NCAAF | 2021/10/23 19:00 | SE Missouri St v Tennessee Martin | L | 30-38 |
| NCAAF | 2021/10/16 19:00 | Murray State v SE Missouri St | L | 32-31 |
| NCAAF | 2021/10/09 20:00 | SE Missouri St v Austin Peay | W | 30-14 |
| NCAAF | 2021/10/02 18:30 | SE Missouri St v Tennessee Tech | L | 17-28 |
Away History
| NCAAF | 2022/09/03 23:00 | SO Illinois v Incarnate Word | L | 29-64 |
| NCAAF | 2021/12/04 20:30 | SO Illinois v North Dakota State | L | 7-38 |
| NCAAF | 2021/11/27 23:00 | SO Illinois v South Dakota | W | 22-10 |
| NCAAF | 2021/11/20 18:00 | Youngstown State v SO Illinois | L | 35-18 |
| NCAAF | 2021/11/13 18:00 | SO Illinois v Indiana State | W | 47-21 |
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | L | 38-28 |
| NCAAF | 2021/10/30 21:00 | SO Illinois v Northern Iowa | L | 16-23 |
| NCAAF | 2021/10/16 19:00 | North Dakota v SO Illinois | W | 28-31 |