Southern Illinois 38-21 Missouri State 2022-10-08 19:00
Stadium: Robert W. Plaster Stadium Round: 1
Home Manager: Bobby Petrino Away Manager: Nick Hill
Head to Head
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | L | 38-28 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | L | 27-30 |
| NCAAF | 2019/11/09 20:00 | Missouri St v SO Illinois | W | 14-37 |
| NCAAF | 2018/10/27 19:00 | Missouri St v SO Illinois | W | 35-49 |
| NCAAF | 2017/11/04 18:00 | SO Illinois v Missouri St | L | 28-36 |
Home History
| NCAAF | 2022/10/01 23:30 | SO Illinois v Illinois State | W | 19-14 |
| NCAAF | 2022/09/24 19:00 | North Dakota v SO Illinois | W | 17-34 |
| NCAAF | 2022/09/17 16:00 | SO Illinois v Northwestern | W | 31-24 |
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | L | 34-31 |
| NCAAF | 2022/09/03 23:00 | SO Illinois v Incarnate Word | L | 29-64 |
| NCAAF | 2021/12/04 20:30 | SO Illinois v North Dakota State | L | 7-38 |
| NCAAF | 2021/11/27 23:00 | SO Illinois v South Dakota | W | 22-10 |
| NCAAF | 2021/11/20 18:00 | Youngstown State v SO Illinois | L | 35-18 |
Away History
| NCAAF | 2022/10/01 17:00 | Missouri St v North Dakota | L | 31-48 |
| NCAAF | 2022/09/24 19:00 | South Dakota State v Missouri St | L | 28-14 |
| NCAAF | 2022/09/17 23:00 | Missouri St v Arkansas | L | 27-38 |
| NCAAF | 2022/09/09 00:00 | Tennessee Martin v Missouri St | W | 30-35 |
| NCAAF | 2022/09/02 00:00 | Missouri St v Central Arkansas | W | 27-14 |
| NCAAF | 2021/11/27 21:00 | Tennessee Martin v Missouri St | L | 32-31 |
| NCAAF | 2021/11/21 02:00 | Missouri St v Utah Tech | W | 55-24 |
| NCAAF | 2021/11/13 20:00 | Northern Iowa v Missouri St | W | 27-34 |