Stadium: O'Brien Stadium Round: 1
Home Manager: Chris Wilkerson Away Manager: Brad Laird
| NCAAF | 2022/10/01 20:30 | Nicholls State v Northwestern State | W | 33-36 |
| NCAAF | 2022/09/24 20:30 | Lamar v Northwestern State | W | 27-35 |
| NCAAF | 2022/09/17 23:00 | Northwestern State v Southern Mississippi | L | 10-64 |
| NCAAF | 2022/09/10 23:00 | Grambling State v Northwestern State | L | 47-21 |
| NCAAF | 2022/09/03 19:00 | Northwestern State v Montana | L | 0-47 |
| NCAAF | 2021/11/20 18:00 | Northwestern State v McNeese State | W | 24-20 |
| NCAAF | 2021/11/14 00:00 | Northwestern State v SE Louisiana | L | 28-56 |
| NCAAF | 2021/11/06 20:00 | Houston Christian v Northwestern State | W | 24-28 |
| NCAAF | 2022/09/24 21:00 | Eastern Illinois v Murray State | W | 35-21 |
| NCAAF | 2022/09/17 23:30 | Eastern Illinois v Illinois State | L | 7-35 |
| NCAAF | 2022/09/10 23:00 | Tennessee Chattanooga v Eastern Illinois | L | 38-20 |
| NCAAF | 2022/09/02 00:00 | Eastern Illinois v Northern Illinois | L | 27-34 |
| NCAAF | 2021/11/20 18:00 | Murray State v Eastern Illinois | L | 20-13 |
| NCAAF | 2021/11/06 19:00 | Eastern Illinois v Austin Peay | L | 26-42 |
| NCAAF | 2021/10/30 18:00 | Eastern Illinois v SE Missouri St | L | 15-38 |
| NCAAF | 2021/10/23 19:00 | Tennessee State v Eastern Illinois | L | 28-0 |