Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: George Quarles Away Manager: Clay Hendrix
| NCAAF | 2021/10/23 18:00 | East Tennessee State v Furman | L | 17-13 |
| NCAAF | 2021/03/13 18:00 | Furman v East Tennessee State | W | 17-13 |
| NCAAF | 2019/09/28 17:00 | East Tennessee State v Furman | W | 10-17 |
| NCAAF | 2018/09/22 23:30 | Furman v East Tennessee State | L | 27-29 |
| NCAAF | 2017/09/30 17:00 | Furman v East Tennessee State | W | 56-35 |
| NCAAF | 2022/09/10 19:30 | Furman v Clemson | L | 12-35 |
| NCAAF | 2022/09/01 23:00 | Furman v North Greenville Crusaders | W | 52-0 |
| NCAAF | 2021/11/20 18:00 | Furman v Samford | W | 41-34 |
| NCAAF | 2021/11/13 19:00 | VMI v Furman | W | 31-37 |
| NCAAF | 2021/11/06 18:00 | Furman v Western Carolina | L | 42-43 |
| NCAAF | 2021/10/30 17:30 | Furman v Tennessee Chattanooga | L | 3-13 |
| NCAAF | 2021/10/23 18:00 | East Tennessee State v Furman | L | 17-13 |
| NCAAF | 2021/10/16 22:00 | The Citadel v Furman | W | 14-24 |
| NCAAF | 2022/09/10 20:00 | East Tennessee State v The Citadel | L | 17-20 |
| NCAAF | 2022/09/01 23:30 | East Tennessee State v Mars Hill Lions | W | 44-7 |
| NCAAF | 2021/12/11 17:00 | East Tennessee State v North Dakota State | L | 3-27 |
| NCAAF | 2021/12/04 19:00 | Kennesaw State v East Tennessee State | W | 31-32 |
| NCAAF | 2021/11/20 18:00 | Mercer v East Tennessee State | W | 35-38 |
| NCAAF | 2021/11/13 19:00 | East Tennessee State v Western Carolina | W | 56-35 |
| NCAAF | 2021/11/06 17:00 | VMI v East Tennessee State | W | 20-27 |
| NCAAF | 2021/10/23 18:00 | East Tennessee State v Furman | W | 17-13 |