Stadium: O'Brien Stadium Round: 1
Home Manager: Chris Wilkerson Away Manager: Dewayne Alexander
| NCAAF | 2021/09/25 18:30 | Eastern Illinois v Tennessee Tech | L | 28-14 |
| NCAAF | 2021/03/21 18:00 | Tennessee Tech v Eastern Illinois | L | 20-28 |
| NCAAF | 2019/09/28 21:00 | Tennessee Tech v Eastern Illinois | W | 40-29 |
| NCAAF | 2018/09/29 23:00 | Eastern Illinois v Tennessee Tech | L | 52-38 |
| NCAAF | 2017/10/07 23:00 | Eastern Illinois v Tennessee Tech | L | 24-23 |
| NCAAF | 2022/10/22 19:00 | Tennessee Tech v Kennesaw State | L | 30-33 |
| NCAAF | 2022/10/15 23:00 | Tennessee State v Tennessee Tech | L | 30-14 |
| NCAAF | 2022/10/08 19:00 | Tennessee Tech v SE Missouri St | L | 20-34 |
| NCAAF | 2022/10/01 19:00 | Tennessee Tech v Tennessee Martin | L | 28-45 |
| NCAAF | 2022/09/17 23:00 | Samford v Tennessee Tech | L | 33-28 |
| NCAAF | 2022/09/10 23:00 | East Texas A&M v Tennessee Tech | W | 25-26 |
| NCAAF | 2022/09/03 00:00 | Tennessee Tech v Kansas | L | 10-56 |
| NCAAF | 2021/11/20 20:00 | Tennessee Tech v Austin Peay | L | 20-48 |
| NCAAF | 2022/10/22 19:00 | Eastern Illinois v Tennessee State | L | 17-37 |
| NCAAF | 2022/10/15 19:00 | Lindenwood v Eastern Illinois | L | 37-34 |
| NCAAF | 2022/10/08 19:00 | Northwestern State v Eastern Illinois | W | 27-35 |
| NCAAF | 2022/09/24 21:00 | Eastern Illinois v Murray State | W | 35-21 |
| NCAAF | 2022/09/17 23:30 | Eastern Illinois v Illinois State | L | 7-35 |
| NCAAF | 2022/09/10 23:00 | Tennessee Chattanooga v Eastern Illinois | L | 38-20 |
| NCAAF | 2022/09/02 00:00 | Eastern Illinois v Northern Illinois | L | 27-34 |
| NCAAF | 2021/11/20 18:00 | Murray State v Eastern Illinois | L | 20-13 |