Stadium: Tucker Stadium Round: 1
Home Manager: Dewayne Alexander Away Manager: Chris Hatcher
| NCAAF | 2021/09/02 23:00 | Tennessee Tech v Samford | W | 14-52 |
| NCAAF | 2019/08/31 23:00 | Samford v Tennessee Tech | L | 58-59 |
| NCAAF | 2022/09/10 20:00 | Samford v Georgia | L | 0-33 |
| NCAAF | 2022/09/01 23:00 | Kennesaw State v Samford | W | 17-27 |
| NCAAF | 2021/11/20 18:00 | Furman v Samford | L | 41-34 |
| NCAAF | 2021/11/13 17:00 | Samford v Florida | L | 52-70 |
| NCAAF | 2021/11/06 19:00 | The Citadel v Samford | W | 14-35 |
| NCAAF | 2021/10/30 17:30 | Samford v VMI | L | 45-46 |
| NCAAF | 2021/10/23 17:00 | Tennessee Chattanooga v Samford | L | 55-13 |
| NCAAF | 2021/10/16 17:30 | Samford v Wofford | W | 27-24 |
| NCAAF | 2022/09/10 23:00 | East Texas A&M v Tennessee Tech | W | 25-26 |
| NCAAF | 2022/09/03 00:00 | Tennessee Tech v Kansas | L | 10-56 |
| NCAAF | 2021/11/20 20:00 | Tennessee Tech v Austin Peay | L | 20-48 |
| NCAAF | 2021/11/13 19:30 | Tennessee Martin v Tennessee Tech | L | 42-3 |
| NCAAF | 2021/11/06 18:00 | Tennessee Tech v Murray State | L | 27-32 |
| NCAAF | 2021/10/23 18:30 | Tennessee Tech v Lynchburg Dragons | W | 56-13 |
| NCAAF | 2021/10/16 19:00 | Tennessee Tech v Tennessee State | L | 13-20 |
| NCAAF | 2021/10/09 18:00 | Tennessee Tech v North Carolina Central | W | 27-16 |