[27] Nicholls State 7-48 South Alabama [43] 2022-09-03 21:00
Stadium: Hancock Whitney Stadium Round: 1
Home Manager: Kane Wommack Away Manager: Tim Rebowe
Head to Head
| NCAAF | 2016/09/24 23:00 | South Alabama v Nicholls State | L | 41-40 |
| NCAAF | 2012/09/08 12:00 | South Alabama v Nicholls State | L | 9-3 |
Home History
| NCAAF | 2021/11/19 00:00 | Nicholls State v SE Louisiana | W | 45-42 |
| NCAAF | 2021/11/13 21:00 | Incarnate Word v Nicholls State | L | 27-23 |
| NCAAF | 2021/11/06 17:00 | Nicholls State v McNeese State | W | 24-14 |
| NCAAF | 2021/10/30 17:00 | Northwestern State v Nicholls State | W | 21-42 |
| NCAAF | 2021/10/23 23:00 | Nicholls State v Houston Christian | W | 44-14 |
| NCAAF | 2021/10/16 16:00 | Nicholls State v Incarnate Word | L | 21-38 |
| NCAAF | 2021/10/09 17:00 | SE Louisiana v Nicholls State | L | 58-48 |
| NCAAF | 2021/10/02 20:00 | Houston Christian v Nicholls State | W | 17-48 |
Away History
| NCAAF | 2021/11/26 20:30 | Coastal Carolina v South Alabama | L | 27-21 |
| NCAAF | 2021/11/21 00:30 | South Alabama v Tennessee | L | 14-60 |
| NCAAF | 2021/11/13 19:30 | South Alabama v Appalachian St | L | 7-31 |
| NCAAF | 2021/11/06 19:30 | South Alabama v Troy | L | 24-31 |
| NCAAF | 2021/10/30 21:00 | Arkansas State v South Alabama | W | 13-31 |
| NCAAF | 2021/10/23 23:00 | South Alabama v UL Monroe | L | 31-41 |
| NCAAF | 2021/10/14 23:30 | Georgia Southern v South Alabama | W | 14-41 |
| NCAAF | 2021/10/09 23:00 | South Alabama v Texas State | L | 31-33 |