[4] Western Kentucky 28-31 Texas San Antonio [2] 2022-10-08 22:00
Stadium: Alamodome Round: 1
Home Manager: Jeff Traylor Away Manager: Tyson Helton
Head to Head
| NCAAF | 2021/12/04 00:00 | Western Kentucky v Texas-San Antonio | L | 41-49 |
| NCAAF | 2021/10/09 23:00 | Texas-San Antonio v Western Kentucky | L | 52-46 |
| NCAAF | 2014/11/22 17:00 | Western Kentucky v Texas-San Antonio | W | 45-7 |
Home History
| NCAAF | 2022/10/01 23:00 | Troy v Western Kentucky | L | 34-27 |
| NCAAF | 2022/09/24 19:30 | Florida Intl v Western Kentucky | W | 0-73 |
| NCAAF | 2022/09/17 16:00 | Western Kentucky v Indiana | L | 30-33 |
| NCAAF | 2022/09/04 04:00 | Western Kentucky v Hawaii | W | 49-17 |
| NCAAF | 2022/08/27 16:00 | Austin Peay v Western Kentucky | W | 27-38 |
| NCAAF Bowl Games | 2021/12/18 16:00 | Appalachian St v Western Kentucky | W | 38-59 |
| NCAAF | 2021/12/04 00:00 | Western Kentucky v Texas-San Antonio | L | 41-49 |
| NCAAF | 2021/11/27 20:30 | Western Kentucky v Marshall | W | 53-21 |
Away History
| NCAAF | 2022/09/30 23:30 | Texas-San Antonio v Middle Tennessee St. | W | 45-30 |
| NCAAF | 2022/09/24 19:30 | Texas Southern Tigers v Texas-San Antonio | W | 24-52 |
| NCAAF | 2022/09/18 00:00 | Texas-San Antonio v Texas | L | 20-41 |
| NCAAF | 2022/09/10 16:00 | Texas-San Antonio v Army | W | 41-38 |
| NCAAF | 2022/09/03 19:30 | Houston v Texas-San Antonio | L | 37-35 |
| NCAAF Bowl Games | 2021/12/22 00:30 | San Diego State v Texas-San Antonio | L | 38-24 |
| NCAAF | 2021/12/04 00:00 | Western Kentucky v Texas-San Antonio | W | 41-49 |
| NCAAF | 2021/11/27 19:00 | Texas-San Antonio v North Texas | L | 23-45 |