Home History
| England U21 Premier League Cup | 2022/12/16 12:00 | Birmingham U21 v Southampton U21 | D | 2-2 |
| England U21 Premier League Cup | 2022/12/02 19:00 | Southampton U21 v Colchester U21 | W | 7-1 |
| England U21 Premier League Cup | 2022/11/26 13:00 | Colchester U21 v Southampton U21 | W | 0-5 |
| England U21 Premier League Cup | 2022/11/21 19:00 | Southampton U21 v Birmingham U21 | W | 4-0 |
| England U21 Premier League Cup | 2022/11/13 12:00 | Everton U21 v Southampton U21 | W | 1-2 |
| England Premier League 2 | 2022/11/07 13:00 | Sunderland U21 v Southampton U21 | W | 1-3 |
| England Premier League 2 | 2022/10/30 12:00 | Southampton U21 v Middlesbrough U21 | W | 8-1 |
| England Premier League 2 | 2022/10/23 13:00 | Newcastle U21 v Southampton U21 | L | 3-2 |
Away History
| England U21 Premier League Cup | 2022/12/19 19:00 | Brighton U21 v Derby U21 | W | 1-2 |
| England U21 Premier League Cup | 2022/12/12 19:00 | Derby U21 v Bournemouth U21 | W | 3-0 |
| England U21 Premier League Cup | 2022/11/28 19:00 | QPR U21 v Derby U21 | W | 0-2 |
| England U21 Premier League Cup | 2022/11/18 19:00 | Derby U21 v Brighton U21 | D | 1-1 |
| England Premier League 2 | 2022/11/07 19:00 | Stoke U21 v Derby U21 | L | 4-0 |
| England Premier League 2 | 2022/10/29 11:30 | Derby U21 v Aston Villa U21 | L | 0-2 |
| England Premier League 2 | 2022/10/10 18:00 | Derby U21 v Nottm Forest U21 | L | 0-1 |
| England Premier League 2 | 2022/09/30 18:00 | Norwich U21 v Derby U21 | L | 2-1 |