Home History
| England EFL Trophy | 2022/10/18 18:00 | Lincoln City v Newcastle U21 | L | 2-0 |
| England Premier League 2 | 2022/10/14 17:00 | Aston Villa U21 v Newcastle U21 | W | 1-2 |
| England Premier League 2 | 2022/09/30 18:00 | Middlesbrough U21 v Newcastle U21 | D | 1-1 |
| England EFL Trophy | 2022/09/20 18:00 | Barnsley v Newcastle U21 | L | 2-0 |
| England Premier League 2 | 2022/09/16 18:00 | Newcastle U21 v Nottm Forest U21 | W | 2-1 |
| England EFL Trophy | 2022/08/30 18:00 | Doncaster v Newcastle U21 | D | 0-0 |
| England Premier League 2 | 2022/08/26 18:00 | Newcastle U21 v Derby U21 | W | 4-0 |
| England Premier League 2 | 2022/08/21 13:00 | Norwich U21 v Newcastle U21 | L | 4-2 |
Away History
| England EFL Trophy | 2022/10/18 18:45 | Newport County v Southampton U21 | L | 2-1 |
| England Premier League 2 | 2022/10/08 11:00 | Southampton U21 v Aston Villa U21 | W | 2-0 |
| England EFL Trophy | 2022/10/04 18:00 | Exeter v Southampton U21 | L | 2-1 |
| England Premier League 2 | 2022/09/16 18:00 | Leeds U21 v Southampton U21 | L | 6-2 |
| England EFL Trophy | 2022/08/30 18:00 | Forest Green v Southampton U21 | L | 3-1 |
| England Premier League 2 | 2022/08/26 18:00 | Southampton U21 v Norwich U21 | D | 1-1 |
| England Premier League 2 | 2022/08/19 18:00 | Stoke U21 v Southampton U21 | W | 0-3 |
| England Premier League 2 | 2022/08/12 17:00 | Southampton U21 v West Brom U21 | W | 4-1 |