Home History
| England EFL Trophy | 2022/10/04 18:00 | Exeter v Southampton U21 | L | 2-1 |
| England Premier League 2 | 2022/09/16 18:00 | Leeds U21 v Southampton U21 | L | 6-2 |
| England EFL Trophy | 2022/08/30 18:00 | Forest Green v Southampton U21 | L | 3-1 |
| England Premier League 2 | 2022/08/26 18:00 | Southampton U21 v Norwich U21 | D | 1-1 |
| England Premier League 2 | 2022/08/19 18:00 | Stoke U21 v Southampton U21 | W | 0-3 |
| England Premier League 2 | 2022/08/12 17:00 | Southampton U21 v West Brom U21 | W | 4-1 |
| England Premier League 2 | 2022/08/08 18:00 | Nottm Forest U21 v Southampton U21 | W | 1-3 |
| England EFL Trophy | 2021/11/09 19:00 | Crawley Town v Southampton U21 | W | 0-4 |
Away History
| England EFL Trophy | 2022/10/04 18:45 | Portsmouth v Aston Villa U21 | L | 5-0 |
| England Premier League 2 | 2022/09/30 18:00 | Aston Villa U21 v West Brom U21 | L | 2-6 |
| England Premier League 2 | 2022/09/18 13:00 | Stoke U21 v Aston Villa U21 | D | 3-3 |
| England EFL Trophy | 2022/08/30 18:00 | AFC Wimbledon v Aston Villa U21 | L | 2-1 |
| England U21 Premier League Cup | 2022/08/26 18:00 | Aston Villa U21 v Peterborough U21 | D | 1-1 |
| England Premier League 2 | 2022/08/19 18:00 | Aston Villa U21 v Leeds U21 | L | 1-2 |
| England Premier League 2 | 2022/08/15 17:00 | Sunderland U21 v Aston Villa U21 | W | 0-4 |
| England Premier League 2 | 2022/08/05 16:00 | Aston Villa U21 v Middlesbrough U21 | D | 3-3 |