Home History
| England Premier League 2 | 2022/08/15 18:00 | Newcastle U21 v Stoke U21 | W | 0-1 |
| England EFL Trophy | 2018/12/04 19:45 | Port Vale v Stoke U21 | L | 4-0 |
| England EFL Trophy | 2018/11/13 19:45 | Carlisle v Stoke U21 | W | 5-6 |
| England Premier League 2 | 2018/10/27 13:00 | Reading U21 v Stoke U21 | L | 2-1 |
| England EFL Trophy | 2018/10/09 18:45 | Morecambe v Stoke U21 | W | 1-2 |
| England EFL Trophy | 2018/09/04 18:45 | Sunderland v Stoke U21 | L | 4-2 |
| England Premier League 2 | 2018/03/03 14:00 | Stoke U21 v Blackburn U21 | L | 0-1 |
| England Premier League 2 | 2017/11/18 14:00 | Stoke U21 v Brighton U21 | L | 2-3 |
Away History
| England Premier League 2 | 2022/08/12 17:00 | Southampton U21 v West Brom U21 | W | 4-1 |
| England Premier League 2 | 2022/08/08 18:00 | Nottm Forest U21 v Southampton U21 | W | 1-3 |
| England EFL Trophy | 2021/11/09 19:00 | Crawley Town v Southampton U21 | W | 0-4 |
| England EFL Trophy | 2021/10/05 18:00 | Charlton v Southampton U21 | L | 4-1 |
| England EFL Trophy | 2021/09/14 18:00 | Leyton Orient v Southampton U21 | L | 1-0 |
| England EFL Trophy | 2020/11/11 19:00 | Milton Keynes Dons v Southampton U21 | W | 1-2 |
| England EFL Trophy | 2020/10/06 18:30 | Northampton v Southampton U21 | L | 5-0 |
| England EFL Trophy | 2020/09/22 18:00 | Stevenage v Southampton U21 | L | 2-1 |