[3] Buffalo 50-31 Eastern Michigan [9] 2022-09-24 16:00
Stadium: Rynearson Stadium Round: 1
Home Manager: Chris Creighton Away Manager: Maurice Linguist
Head to Head
| NCAAF | 2019/11/02 16:00 | Buffalo v Eastern Michigan | W | 43-14 |
| NCAAF | 2018/09/15 22:00 | Eastern Michigan v Buffalo | W | 28-35 |
| NCAAF | 2014/10/11 17:00 | Eastern Michigan v Buffalo | L | 37-27 |
| NCAAF | 2011/11/12 12:00 | Eastern Michigan v Buffalo | L | 30-17 |
| NCAAF | 2010/11/20 12:00 | Buffalo v Eastern Michigan | L | 17-21 |
| NCAAF | 2005/11/19 12:00 | Buffalo v Eastern Michigan | L | 14-38 |
| NCAAF | 2004/09/02 23:00 | Eastern Michigan v Buffalo | L | 37-34 |
| NCAAF | 2001/10/27 12:00 | Eastern Michigan v Buffalo | L | 24-20 |
Home History
| NCAAF | 2022/09/17 17:00 | Buffalo v Coastal Carolina | L | 26-38 |
| NCAAF | 2022/09/10 22:00 | Holy Cross v Buffalo | L | 37-31 |
| NCAAF | 2022/09/03 16:00 | Buffalo v Maryland | L | 10-31 |
| NCAAF | 2021/11/24 00:00 | Buffalo v Ball State | L | 3-20 |
| NCAAF | 2021/11/18 00:00 | Northern Illinois v Buffalo | L | 33-27 |
| NCAAF | 2021/11/10 00:00 | Buffalo v Miami Ohio | L | 18-45 |
| NCAAF | 2021/10/30 16:00 | Bowling Green v Buffalo | L | 56-44 |
| NCAAF | 2021/10/23 19:30 | Buffalo v Akron | W | 45-10 |
Away History
| NCAAF | 2022/09/18 03:00 | Eastern Michigan v Arizona State | W | 30-21 |
| NCAAF | 2022/09/10 23:00 | Eastern Michigan v Lafayette | L | 21-49 |
| NCAAF | 2022/09/02 23:00 | Eastern Kentucky v Eastern Michigan | W | 34-42 |
| NCAAF Bowl Games | 2021/12/18 22:45 | Eastern Michigan v Liberty | L | 20-56 |
| NCAAF | 2021/11/26 17:00 | Eastern Michigan v Central Michigan | L | 10-31 |
| NCAAF | 2021/11/17 00:30 | Western Michigan v Eastern Michigan | W | 21-22 |
| NCAAF | 2021/11/10 01:00 | Ohio v Eastern Michigan | L | 34-26 |
| NCAAF | 2021/11/02 23:30 | Eastern Michigan v Toledo | W | 52-49 |