[4] Mississippi 20-45 LSU [28] 2022-10-22 19:30
Stadium: Tiger Stadium Round: 1
Home Manager: Brian Kelly Away Manager: Lane Kiffin
Head to Head
| NCAAF | 2021/10/23 19:30 | LSU v Mississippi | W | 17-31 |
| NCAAF | 2020/12/19 20:30 | Mississippi v LSU | L | 48-53 |
| NCAAF | 2019/11/17 00:00 | LSU v Mississippi | L | 58-37 |
| NCAAF | 2018/09/30 01:15 | Mississippi v LSU | L | 16-45 |
| NCAAF | 2017/10/21 23:15 | LSU v Mississippi | L | 40-24 |
| NCAAF | 2016/10/23 01:00 | Mississippi v LSU | L | 21-38 |
| NCAAF | 2015/11/21 20:30 | Mississippi v LSU | W | 38-17 |
| NCAAF | 2014/10/25 23:15 | LSU v Mississippi | L | 10-7 |
Home History
| NCAAF | 2022/10/15 16:00 | Auburn v Mississippi | W | 34-48 |
| NCAAF | 2022/10/08 20:00 | Mississippi v Vanderbilt | W | 52-28 |
| NCAAF | 2022/10/01 16:00 | Kentucky v Mississippi | W | 19-22 |
| NCAAF | 2022/09/24 20:00 | Tulsa v Mississippi | W | 27-35 |
| NCAAF | 2022/09/17 19:30 | Mississippi v Georgia Tech | W | 42-0 |
| NCAAF | 2022/09/10 23:00 | Central Arkansas v Mississippi | W | 3-59 |
| NCAAF | 2022/09/03 20:00 | Troy v Mississippi | W | 10-28 |
| NCAAF Bowl Games | 2022/01/02 01:45 | Baylor v Mississippi | L | 21-7 |
Away History
| NCAAF | 2022/10/15 23:00 | LSU v Florida | W | 45-35 |
| NCAAF | 2022/10/08 16:00 | Tennessee v LSU | L | 40-13 |
| NCAAF | 2022/10/01 23:00 | LSU v Auburn | W | 21-17 |
| NCAAF | 2022/09/24 23:30 | New Mexico v LSU | W | 0-38 |
| NCAAF | 2022/09/17 22:00 | Mississippi State v LSU | W | 16-31 |
| NCAAF | 2022/09/10 23:30 | Southern v LSU | W | 17-65 |
| NCAAF | 2022/09/04 23:30 | Florida State v LSU | L | 24-23 |
| NCAAF Bowl Games | 2022/01/05 02:00 | LSU v Kansas State | L | 20-42 |