[1] Northwestern 7-17 Penn State [5] 2022-10-01 19:30
Stadium: Beaver Stadium Round: 1
Home Manager: James Franklin Away Manager: Pat Fitzgerald
Head to Head
| NCAAF | 2017/10/07 16:00 | Penn State v Northwestern | L | 31-7 |
| NCAAF | 2015/11/07 17:00 | Northwestern v Penn State | W | 23-21 |
| NCAAF | 2014/09/27 16:00 | Penn State v Northwestern | W | 6-29 |
| NCAAF | 2012/10/06 12:00 | Penn State v Northwestern | L | 39-28 |
| NCAAF | 2011/10/22 12:00 | Northwestern v Penn State | L | 24-34 |
| NCAAF | 2010/11/06 12:00 | Penn State v Northwestern | L | 35-21 |
| NCAAF | 2009/10/31 12:00 | Northwestern v Penn State | L | 13-34 |
| NCAAF | 2006/09/30 12:00 | Penn State v Northwestern | L | 33-7 |
Home History
| NCAAF | 2022/09/24 23:30 | Miami Ohio v Northwestern | L | 17-14 |
| NCAAF | 2022/09/17 16:00 | SO Illinois v Northwestern | L | 31-24 |
| NCAAF | 2022/09/10 16:00 | Duke v Northwestern | L | 31-23 |
| NCAAF | 2022/08/27 16:30 | Northwestern v Nebraska | W | 31-28 |
| NCAAF | 2021/11/27 20:30 | Northwestern v Illinois | L | 14-47 |
| NCAAF | 2021/11/20 17:00 | Purdue v Northwestern | L | 32-14 |
| NCAAF | 2021/11/13 17:00 | Northwestern v Wisconsin | L | 7-35 |
| NCAAF | 2021/11/06 23:00 | Iowa v Northwestern | L | 17-12 |
Away History
| NCAAF | 2022/09/24 16:00 | Central Michigan v Penn State | W | 14-33 |
| NCAAF | 2022/09/17 19:30 | Penn State v Auburn | W | 41-12 |
| NCAAF | 2022/09/10 16:00 | Ohio v Penn State | W | 10-46 |
| NCAAF | 2022/09/02 00:00 | Penn State v Purdue | W | 35-31 |
| NCAAF Bowl Games | 2022/01/01 17:00 | Arkansas v Penn State | L | 24-10 |
| NCAAF | 2021/11/27 20:30 | Penn State v Michigan State | L | 27-30 |
| NCAAF | 2021/11/20 17:00 | Rutgers v Penn State | W | 0-28 |
| NCAAF | 2021/11/13 17:00 | Michigan v Penn State | L | 21-17 |