[14] Louisville 33-34 Boston College [13] 2022-10-01 16:00
Stadium: Alumni Stadium Round: 1
Home Manager: Jeff Hafley Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2021/10/23 20:00 | Boston College v Louisville | W | 14-28 |
| NCAAF | 2020/11/28 21:00 | Louisville v Boston College | L | 27-34 |
| NCAAF | 2019/10/05 16:30 | Boston College v Louisville | W | 39-41 |
| NCAAF | 2018/10/13 16:30 | Louisville v Boston College | L | 20-38 |
| NCAAF | 2017/10/14 16:20 | Boston College v Louisville | L | 45-42 |
| NCAAF | 2016/11/05 16:00 | Louisville v Boston College | W | 52-7 |
| NCAAF | 2015/10/24 16:30 | Louisville v Boston College | W | 17-14 |
| NCAAF | 2014/11/09 00:15 | Boston College v Louisville | W | 19-38 |
Home History
| NCAAF | 2022/09/24 16:00 | South Florida v Louisville | W | 3-41 |
| NCAAF | 2022/09/16 23:30 | Florida State v Louisville | L | 35-31 |
| NCAAF | 2022/09/09 23:30 | Louisville v Central Florida | W | 20-14 |
| NCAAF | 2022/09/04 00:00 | Louisville v Syracuse | L | 7-31 |
| NCAAF Bowl Games | 2021/12/28 20:15 | Louisville v Air Force | L | 28-31 |
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2021/11/19 00:30 | Louisville v Duke | W | 62-22 |
| NCAAF | 2021/11/13 17:00 | Syracuse v Louisville | W | 3-41 |
Away History
| NCAAF | 2022/09/25 00:00 | Boston College v Florida State | L | 14-44 |
| NCAAF | 2022/09/17 23:30 | Maine v Boston College | W | 17-38 |
| NCAAF | 2022/09/11 00:00 | Boston College v Virginia Tech | L | 10-27 |
| NCAAF | 2022/09/03 16:00 | Rutgers v Boston College | L | 22-21 |
| NCAAF | 2021/11/27 17:00 | Wake Forest v Boston College | L | 41-10 |
| NCAAF | 2021/11/20 17:00 | Florida State v Boston College | L | 26-23 |
| NCAAF | 2021/11/13 20:30 | Boston College v Georgia Tech | W | 41-30 |
| NCAAF | 2021/11/05 23:30 | Virginia Tech v Boston College | W | 3-17 |