[9] Oklahoma 27-13 Iowa State [10] 2022-10-29 16:00
Stadium: Jack Trice Stadium Round: 1
Home Manager: Matt Campbell Away Manager: Brent Venables
Head to Head
| NCAAF | 2021/11/20 17:00 | Iowa State v Oklahoma | W | 21-28 |
| NCAAF | 2020/12/19 17:00 | Oklahoma v Iowa State | W | 27-21 |
| NCAAF | 2020/10/03 23:30 | Oklahoma v Iowa State | L | 30-37 |
| NCAAF | 2019/11/10 01:00 | Iowa State v Oklahoma | W | 41-42 |
| NCAAF | 2018/09/15 16:00 | Oklahoma v Iowa State | W | 37-27 |
| NCAAF | 2017/10/07 16:00 | Iowa State v Oklahoma | L | 38-31 |
| NCAAF | 2016/11/03 23:30 | Oklahoma v Iowa State | W | 34-24 |
| NCAAF | 2015/11/08 00:00 | Oklahoma v Iowa State | W | 52-16 |
Home History
| NCAAF | 2022/10/15 16:00 | Kansas v Oklahoma | W | 42-52 |
| NCAAF | 2022/10/08 16:00 | Texas v Oklahoma | L | 49-0 |
| NCAAF | 2022/10/01 16:00 | Oklahoma v TCU | L | 24-55 |
| NCAAF | 2022/09/25 00:00 | Kansas State v Oklahoma | L | 41-34 |
| NCAAF | 2022/09/17 16:00 | Oklahoma v Nebraska | W | 49-14 |
| NCAAF | 2022/09/10 23:00 | Kent State v Oklahoma | W | 3-33 |
| NCAAF | 2022/09/03 19:30 | UTEP v Oklahoma | W | 13-45 |
| NCAAF Bowl Games | 2021/12/30 02:15 | Oregon v Oklahoma | W | 32-47 |
Away History
| NCAAF | 2022/10/15 16:00 | Iowa State v Texas | L | 21-24 |
| NCAAF | 2022/10/08 23:30 | Kansas State v Iowa State | L | 10-9 |
| NCAAF | 2022/10/01 19:30 | Iowa State v Kansas | L | 11-14 |
| NCAAF | 2022/09/24 16:00 | Baylor v Iowa State | L | 31-24 |
| NCAAF | 2022/09/17 18:00 | Ohio v Iowa State | W | 10-43 |
| NCAAF | 2022/09/10 20:00 | Iowa State v Iowa | W | 10-7 |
| NCAAF | 2022/09/03 18:00 | SE Missouri St v Iowa State | W | 10-42 |
| NCAAF Bowl Games | 2021/12/29 22:45 | Iowa State v Clemson | L | 13-20 |