[8] Northern Illinois 39-10 Eastern Michigan [10] 2022-10-15 19:30
Stadium: Rynearson Stadium Round: 1
Home Manager: Chris Creighton Away Manager: Thomas Hammock
Head to Head
| NCAAF | 2021/10/02 18:30 | Eastern Michigan v Northern Illinois | W | 20-27 |
| NCAAF | 2020/12/12 17:00 | Northern Illinois v Eastern Michigan | L | 33-41 |
| NCAAF | 2019/11/20 00:30 | Eastern Michigan v Northern Illinois | L | 45-17 |
| NCAAF | 2018/09/29 22:00 | Northern Illinois v Eastern Michigan | W | 26-23 |
| NCAAF | 2017/10/27 01:00 | Northern Illinois v Eastern Michigan | W | 30-27 |
| NCAAF | 2016/11/17 01:00 | Northern Illinois v Eastern Michigan | W | 31-24 |
| NCAAF | 2015/10/24 19:30 | Northern Illinois v Eastern Michigan | W | 49-21 |
| NCAAF | 2014/10/25 17:00 | Eastern Michigan v Northern Illinois | W | 17-28 |
Home History
| NCAAF | 2022/10/08 19:30 | Toledo v Northern Illinois | L | 52-32 |
| NCAAF | 2022/10/01 18:00 | Northern Illinois v Ball State | L | 38-44 |
| NCAAF | 2022/09/24 23:00 | Northern Illinois v Kentucky | L | 23-31 |
| NCAAF | 2022/09/17 19:30 | Vanderbilt v Northern Illinois | L | 38-28 |
| NCAAF | 2022/09/10 23:00 | Northern Illinois v Tulsa | L | 35-38 |
| NCAAF | 2022/09/02 00:00 | Eastern Illinois v Northern Illinois | W | 27-34 |
| NCAAF Bowl Games | 2021/12/17 23:00 | Coastal Carolina v Northern Illinois | L | 47-41 |
| NCAAF | 2021/12/04 17:00 | Kent State v Northern Illinois | W | 23-41 |
Away History
| NCAAF | 2022/10/08 16:00 | Eastern Michigan v Western Michigan | W | 45-23 |
| NCAAF | 2022/10/01 18:00 | Massachusetts v Eastern Michigan | W | 13-20 |
| NCAAF | 2022/09/24 16:00 | Buffalo v Eastern Michigan | L | 50-31 |
| NCAAF | 2022/09/18 03:00 | Eastern Michigan v Arizona State | W | 30-21 |
| NCAAF | 2022/09/10 23:00 | Eastern Michigan v Lafayette | L | 21-49 |
| NCAAF | 2022/09/02 23:00 | Eastern Kentucky v Eastern Michigan | W | 34-42 |
| NCAAF Bowl Games | 2021/12/18 22:45 | Eastern Michigan v Liberty | L | 20-56 |
| NCAAF | 2021/11/26 17:00 | Eastern Michigan v Central Michigan | L | 10-31 |