Louisville 13-26 Kentucky 2022-11-26 20:00
Stadium: Kroger Field Round: 1
Home Manager: Mark Stoops Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2021/11/28 00:30 | Kentucky v Louisville | L | 52-21 |
| NCAAF | 2019/11/30 17:00 | Louisville v Kentucky | L | 13-45 |
| NCAAF | 2018/11/25 00:00 | Kentucky v Louisville | L | 56-10 |
| NCAAF | 2017/11/25 17:00 | Louisville v Kentucky | W | 44-17 |
| NCAAF | 2016/11/26 17:00 | Kentucky v Louisville | L | 41-38 |
| NCAAF | 2015/11/28 17:00 | Kentucky v Louisville | W | 24-38 |
| NCAAF | 2014/11/29 17:00 | Louisville v Kentucky | W | 44-40 |
| NCAAF | 2012/09/02 12:00 | Louisville v Kentucky | W | 32-14 |
Home History
| NCAAF | 2022/11/19 20:30 | NC State v Louisville | W | 10-25 |
| NCAAF | 2022/11/12 20:30 | Louisville v Clemson | L | 16-31 |
| NCAAF | 2022/11/05 23:30 | James Madison v Louisville | W | 10-34 |
| NCAAF | 2022/10/29 19:30 | Wake Forest v Louisville | W | 21-48 |
| NCAAF | 2022/10/23 00:00 | Pittsburgh v Louisville | W | 10-24 |
| NCAAF | 2022/10/08 16:00 | Louisville v Virginia | W | 34-17 |
| NCAAF | 2022/10/01 16:00 | Louisville v Boston College | L | 33-34 |
| NCAAF | 2022/09/24 16:00 | South Florida v Louisville | W | 3-41 |
Away History
| NCAAF | 2022/11/19 20:30 | Georgia v Kentucky | L | 16-6 |
| NCAAF | 2022/11/12 17:00 | Vanderbilt v Kentucky | L | 24-21 |
| NCAAF | 2022/11/05 16:00 | Kentucky v Missouri | W | 21-17 |
| NCAAF | 2022/10/29 23:00 | Kentucky v Tennessee | L | 6-44 |
| NCAAF | 2022/10/15 23:30 | Mississippi State v Kentucky | W | 17-27 |
| NCAAF | 2022/10/08 23:30 | South Carolina v Kentucky | L | 24-14 |
| NCAAF | 2022/10/01 16:00 | Kentucky v Mississippi | L | 19-22 |
| NCAAF | 2022/09/24 23:00 | Northern Illinois v Kentucky | W | 23-31 |