Away History
| England EFL Trophy | 2021/11/09 19:00 | Crawley Town v Southampton U21 | W | 0-4 |
| England EFL Trophy | 2021/10/05 18:00 | Charlton v Southampton U21 | L | 4-1 |
| England EFL Trophy | 2021/09/14 18:00 | Leyton Orient v Southampton U21 | L | 1-0 |
| England EFL Trophy | 2020/11/11 19:00 | Milton Keynes Dons v Southampton U21 | W | 1-2 |
| England EFL Trophy | 2020/10/06 18:30 | Northampton v Southampton U21 | L | 5-0 |
| England EFL Trophy | 2020/09/22 18:00 | Stevenage v Southampton U21 | L | 2-1 |
| England EFL Trophy | 2019/11/05 19:45 | Coventry v Southampton U21 | L | 3-2 |
| England EFL Trophy | 2019/10/01 18:00 | Walsall v Southampton U21 | L | 1-0 |