[1] James Madison 10-34 Louisville [14] 2022-11-05 23:30
Stadium: L&N Federal Credit Union Stadium Round: 1
Home Manager: Scott Satterfield Away Manager: Curt Cignetti
Home History
| NCAAF | 2022/10/22 19:30 | Marshall v James Madison | L | 26-12 |
| NCAAF | 2022/10/15 20:00 | James Madison v Georgia Southern | L | 38-45 |
| NCAAF | 2022/10/08 23:00 | James Madison v Arkansas State | W | 42-20 |
| NCAAF | 2022/10/01 17:30 | Texas State v James Madison | W | 13-40 |
| NCAAF | 2022/09/24 19:30 | James Madison v Appalachian St | W | 32-28 |
| NCAAF | 2022/09/10 20:00 | Norfolk State v James Madison | W | 7-63 |
| NCAAF | 2022/09/03 22:00 | Middle Tennessee St. v James Madison | W | 7-44 |
| NCAAF | 2021/12/18 02:15 | James Madison v North Dakota State | L | 14-20 |
Away History
| NCAAF | 2022/10/29 19:30 | Wake Forest v Louisville | W | 21-48 |
| NCAAF | 2022/10/23 00:00 | Pittsburgh v Louisville | W | 10-24 |
| NCAAF | 2022/10/08 16:00 | Louisville v Virginia | W | 34-17 |
| NCAAF | 2022/10/01 16:00 | Louisville v Boston College | L | 33-34 |
| NCAAF | 2022/09/24 16:00 | South Florida v Louisville | W | 3-41 |
| NCAAF | 2022/09/16 23:30 | Florida State v Louisville | L | 35-31 |
| NCAAF | 2022/09/09 23:30 | Louisville v Central Florida | W | 20-14 |
| NCAAF | 2022/09/04 00:00 | Louisville v Syracuse | L | 7-31 |