Stadium: Franklin Field Round: 1
Home Manager: Ray Priore Away Manager:
| NCAAF | 2022/09/10 17:00 | Colgate v Maine | W | 21-18 |
| NCAAF | 2022/09/04 00:00 | Colgate v Stanford | L | 10-41 |
| NCAAF | 2021/11/20 17:00 | Fordham v Colgate | W | 31-45 |
| NCAAF | 2021/11/13 17:30 | Colgate v Lafayette | W | 20-13 |
| NCAAF | 2021/10/30 17:00 | Bucknell v Colgate | W | 10-33 |
| NCAAF | 2021/10/23 21:00 | Colgate v Holy Cross | L | 10-42 |
| NCAAF | 2021/10/15 23:00 | Colgate v Cornell Big Red | L | 20-34 |
| NCAAF | 2021/10/09 16:30 | Colgate v Brown | L | 10-31 |
| NCAAF | 2021/11/20 18:00 | Princeton v Pennsylvania | L | 34-14 |
| NCAAF | 2021/11/13 17:00 | Pennsylvania v Harvard | L | 7-23 |
| NCAAF | 2021/11/06 17:00 | Cornell Big Red v Pennsylvania | L | 15-12 |
| NCAAF | 2021/10/30 17:00 | Brown v Pennsylvania | W | 17-45 |
| NCAAF | 2021/10/23 16:00 | Pennsylvania v Yale | L | 28-42 |
| NCAAF | 2021/10/16 17:30 | Pennsylvania v Columbia | L | 14-23 |
| NCAAF | 2021/10/09 17:00 | Lehigh v Pennsylvania | W | 0-20 |
| NCAAF | 2021/10/01 23:00 | Dartmouth v Pennsylvania | L | 31-7 |