Stadium: Arthur J. Rooney Athletic Field Round: 1
Home Manager: Jerry Schmitt Away Manager: Mark Nofri
| NCAAF | 2021/10/23 16:00 | Duquesne v Sacred Heart | W | 13-31 |
| NCAAF | 2021/04/11 18:00 | Sacred Heart v Duquesne | W | 34-27 |
| NCAAF | 2021/03/07 17:00 | Sacred Heart v Duquesne | L | 27-30 |
| NCAAF | 2019/10/19 16:00 | Duquesne v Sacred Heart | L | 20-6 |
| NCAAF | 2018/11/10 17:00 | Duquesne v Sacred Heart | L | 28-24 |
| NCAAF | 2017/10/28 16:00 | Sacred Heart v Duquesne | L | 21-37 |
| NCAAF | 2022/10/29 16:00 | St.Francis (PA) v Sacred Heart | L | 44-14 |
| NCAAF | 2022/10/22 17:00 | Sacred Heart v Merrimack | L | 25-31 |
| NCAAF | 2022/10/15 17:00 | Stonehill v Sacred Heart | W | 27-40 |
| NCAAF | 2022/10/01 17:00 | Norfolk State v Sacred Heart | W | 14-31 |
| NCAAF | 2022/09/24 18:00 | Dartmouth v Sacred Heart | W | 31-38 |
| NCAAF | 2022/09/17 16:00 | Sacred Heart v Morgan State | L | 9-24 |
| NCAAF | 2022/09/10 22:00 | Sacred Heart v Central Connecticut | W | 14-10 |
| NCAAF | 2022/09/03 16:30 | Sacred Heart v Lafayette | L | 0-6 |
| NCAAF | 2022/10/29 16:00 | LIU Brooklyn v Duquesne | L | 50-48 |
| NCAAF | 2022/10/22 16:00 | Duquesne v Central Connecticut | W | 30-6 |
| NCAAF | 2022/10/08 17:00 | Merrimack v Duquesne | L | 28-21 |
| NCAAF | 2022/10/01 16:00 | Duquesne v Stonehill | L | 20-24 |
| NCAAF | 2022/09/18 04:00 | Duquesne v Hawaii | L | 14-24 |
| NCAAF | 2022/09/10 16:00 | Duquesne v Thomas More Saints | W | 34-14 |
| NCAAF | 2022/09/03 18:00 | Duquesne v Youngstown State | L | 14-31 |
| NCAAF | 2022/08/27 22:30 | Duquesne v Florida State | L | 7-47 |