Stadium: A.W. Mumford Stadium Round: 1
Home Manager: Eric Dooley Away Manager:
| NCAAF | 2022/10/15 23:00 | Alcorn State v Southern | W | 17-21 |
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | W | 45-13 |
| NCAAF | 2022/10/01 23:00 | Arkansas Pine Bluff v Southern | W | 3-59 |
| NCAAF | 2022/09/17 21:00 | Southern v Texas Southern Tigers | L | 0-24 |
| NCAAF | 2022/09/10 23:30 | Southern v LSU | L | 17-65 |
| NCAAF | 2022/09/03 23:00 | Southern v Florida Memorial University Lions | W | 86-0 |
| NCAAF | 2021/11/27 22:00 | Southern v Grambling State | L | 26-29 |
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | L | 21-17 |
| NCAAF | 2022/10/15 17:30 | South Carolina State v Lynchburg Dragons | L | 36-0 |
| NCAAF | 2022/10/08 19:00 | Savannah State v Lynchburg Dragons | L | 28-14 |
| NCAAF | 2022/10/01 16:00 | Morgan State v Lynchburg Dragons | L | 44-10 |
| NCAAF | 2022/09/24 20:00 | North Carolina Central v Lynchburg Dragons | L | 59-14 |
| NCAAF | 2022/09/17 18:00 | Delaware State v Lynchburg Dragons | L | 35-19 |
| NCAAF | 2022/09/10 17:00 | Presbyterian v Lynchburg Dragons | L | 21-13 |
| NCAAF | 2022/09/01 23:00 | Virginia Union Panthers v Lynchburg Dragons | L | 77-0 |
| NCAAF | 2021/10/23 18:30 | Tennessee Tech v Lynchburg Dragons | L | 56-13 |