Stadium: Drake Stadium Round: 1
Home Manager: Todd Stepsis Away Manager:
| NCAAF | 2022/09/03 19:30 | Drake Bulldogs v North Dakota State | L | 14-56 |
| NCAAF | 2021/11/20 18:00 | Drake Bulldogs v Davidson Wildcats | L | 14-45 |
| NCAAF | 2021/11/13 18:00 | St. Thomas (MN) v Drake Bulldogs | L | 21-14 |
| NCAAF | 2021/11/06 16:00 | Drake Bulldogs v Marist | L | 0-7 |
| NCAAF | 2021/10/16 21:00 | Drake Bulldogs v San Diego | L | 10-13 |
| NCAAF | 2021/10/09 17:00 | Dayton v Drake Bulldogs | L | 28-10 |
| NCAAF | 2021/10/02 16:00 | Drake Bulldogs v Butler | W | 6-3 |
| NCAAF | 2021/09/25 17:00 | Valparaiso v Drake Bulldogs | L | 24-21 |
| NCAAF | 2022/09/01 23:00 | Missouri S&t Miners v South Dakota Mines Hardrockers | L | 20-43 |
| NCAAF | 2021/11/13 19:00 | Southwest Baptist University Bearcats v Missouri S&t Miners | W | 41-42 |
| NCAAF | 2021/11/06 18:00 | Missouri S&t Miners v Lindenwood | L | 16-43 |
| NCAAF | 2021/10/30 18:00 | Missouri S&t Miners v Indianapolis Greyhounds | W | 31-28 |
| NCAAF | 2021/10/23 18:00 | McKendree v Missouri S&t Miners | W | 31-37 |
| NCAAF | 2021/10/16 18:00 | Missouri S&t Miners v William Jewell College Cardinals | W | 37-16 |
| NCAAF | 2021/10/09 18:00 | Missouri S&t Miners v Truman Bulldogs | L | 21-38 |
| NCAAF | 2021/10/02 18:00 | Quincy v Missouri S&t Miners | L | 31-28 |