Stadium: Shell Energy Stadium Round: 1
Home Manager: Clarence McKinney Away Manager: Deion Sanders
| NCAAF | 2022/10/29 18:00 | Southern v Jackson State | W | 0-35 |
| NCAAF | 2022/10/22 19:00 | Campbell v Jackson State | W | 14-22 |
| NCAAF | 2022/10/15 20:00 | Jackson State v Bethune Cookman | W | 48-8 |
| NCAAF | 2022/10/08 19:00 | Jackson State v Alabama State | W | 26-12 |
| NCAAF | 2022/09/24 18:00 | Mississippi Valley State v Jackson State | W | 7-49 |
| NCAAF | 2022/09/17 18:00 | Grambling State v Jackson State | W | 24-66 |
| NCAAF | 2022/09/10 23:00 | Jackson State v Tennessee State | W | 16-3 |
| NCAAF | 2022/09/04 19:00 | Florida A&M v Jackson State | W | 3-59 |
| NCAAF | 2022/10/29 19:00 | Texas Southern Tigers v Lincoln Oaklanders | W | 37-2 |
| NCAAF | 2022/10/22 19:00 | Texas Southern Tigers v Alcorn State | W | 34-27 |
| NCAAF | 2022/10/08 19:00 | Texas Southern Tigers v Arkansas Pine Bluff | W | 24-17 |
| NCAAF | 2022/10/01 23:00 | Alabama State v Texas Southern Tigers | L | 16-13 |
| NCAAF | 2022/09/24 19:30 | Texas Southern Tigers v Texas-San Antonio | L | 24-52 |
| NCAAF | 2022/09/17 21:00 | Southern v Texas Southern Tigers | W | 0-24 |
| NCAAF | 2022/09/10 23:30 | Texas Southern Tigers v North Texas | L | 27-59 |
| NCAAF | 2022/09/03 23:00 | Texas Southern Tigers v Prairie View | L | 23-40 |