Stadium: Panther Stadium at Blackshear Field Round: 1
Home Manager: Bubba McDowell Away Manager: Eric Dooley
| NCAAF | 2021/10/23 23:00 | Prairie View v Southern | L | 48-21 |
| NCAAF | 2019/10/12 23:00 | Prairie View v Southern | W | 28-34 |
| NCAAF | 2018/10/13 22:00 | Southern v Prairie View | W | 38-0 |
| NCAAF | 2017/11/04 21:00 | Southern v Prairie View | W | 37-31 |
| NCAAF | 2022/10/01 23:00 | Arkansas Pine Bluff v Southern | W | 3-59 |
| NCAAF | 2022/09/17 21:00 | Southern v Texas Southern Tigers | L | 0-24 |
| NCAAF | 2022/09/10 23:30 | Southern v LSU | L | 17-65 |
| NCAAF | 2022/09/03 23:00 | Southern v Florida Memorial University Lions | W | 86-0 |
| NCAAF | 2021/11/27 22:00 | Southern v Grambling State | L | 26-29 |
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | L | 21-17 |
| NCAAF | 2021/11/06 23:00 | Florida A&M v Southern | L | 29-17 |
| NCAAF | 2021/10/30 23:00 | Alcorn State v Southern | W | 35-38 |
| NCAAF | 2022/10/01 23:00 | Prairie View v Grambling State | W | 34-14 |
| NCAAF | 2022/09/24 22:00 | Prairie View v Alabama State | W | 25-15 |
| NCAAF | 2022/09/17 23:00 | Incarnate Word v Prairie View | L | 31-14 |
| NCAAF | 2022/09/11 00:00 | Prairie View v Abilene Christian | L | 13-21 |
| NCAAF | 2022/09/03 23:00 | Texas Southern Tigers v Prairie View | W | 23-40 |
| NCAAF | 2021/12/04 21:00 | Prairie View v Jackson State | L | 10-27 |
| NCAAF | 2021/11/27 20:00 | Mississippi Valley State v Prairie View | L | 24-19 |
| NCAAF | 2021/11/20 17:00 | Prairie View v Texas A&M | L | 3-52 |