Southern 0-35 Jackson State 2022-10-29 18:00
Stadium: Mississippi Veterans Memorial Stadium Round: 1
Home Manager: Deion Sanders Away Manager: Eric Dooley
Head to Head
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | L | 21-17 |
| NCAAF | 2021/04/03 21:00 | Southern v Jackson State | W | 34-14 |
| NCAAF | 2019/11/16 20:00 | Southern v Jackson State | W | 40-34 |
| NCAAF | 2018/10/27 23:00 | Southern v Jackson State | W | 41-7 |
| NCAAF | 2017/10/21 23:00 | Jackson State v Southern | W | 17-35 |
Home History
| NCAAF | 2022/10/22 21:00 | Southern v Lynchburg Dragons | W | 51-7 |
| NCAAF | 2022/10/15 23:00 | Alcorn State v Southern | W | 17-21 |
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | W | 45-13 |
| NCAAF | 2022/10/01 23:00 | Arkansas Pine Bluff v Southern | W | 3-59 |
| NCAAF | 2022/09/17 21:00 | Southern v Texas Southern Tigers | L | 0-24 |
| NCAAF | 2022/09/10 23:30 | Southern v LSU | L | 17-65 |
| NCAAF | 2022/09/03 23:00 | Southern v Florida Memorial University Lions | W | 86-0 |
| NCAAF | 2021/11/27 22:00 | Southern v Grambling State | L | 26-29 |
Away History
| NCAAF | 2022/10/22 19:00 | Campbell v Jackson State | W | 14-22 |
| NCAAF | 2022/10/15 20:00 | Jackson State v Bethune Cookman | W | 48-8 |
| NCAAF | 2022/10/08 19:00 | Jackson State v Alabama State | W | 26-12 |
| NCAAF | 2022/09/24 18:00 | Mississippi Valley State v Jackson State | W | 7-49 |
| NCAAF | 2022/09/17 18:00 | Grambling State v Jackson State | W | 24-66 |
| NCAAF | 2022/09/10 23:00 | Jackson State v Tennessee State | W | 16-3 |
| NCAAF | 2022/09/04 19:00 | Florida A&M v Jackson State | W | 3-59 |
| NCAAF Bowl Games | 2021/12/18 17:00 | South Carolina State v Jackson State | L | 31-10 |