Stadium: Rice-Totten Stadium Round: 1
Home Manager: Vincent Dancy Away Manager: Terry Sims
| NCAAF | 2021/10/09 20:00 | Mississippi Valley State v Bethune Cookman | L | 20-14 |
| NCAAF | 2019/09/21 23:00 | Bethune Cookman v Mississippi Valley State | W | 22-6 |
| NCAAF | 2018/10/06 20:00 | Mississippi Valley State v Bethune Cookman | W | 27-41 |
| NCAAF | 2022/10/15 20:00 | Jackson State v Bethune Cookman | L | 48-8 |
| NCAAF | 2022/10/08 22:00 | Bethune Cookman v Tennessee State | L | 17-41 |
| NCAAF | 2022/10/01 19:00 | Bethune Cookman v Alabama | L | 27-35 |
| NCAAF | 2022/09/24 18:00 | Grambling State v Bethune Cookman | W | 19-36 |
| NCAAF | 2022/09/10 20:00 | South Carolina State v Bethune Cookman | L | 33-9 |
| NCAAF | 2022/09/03 19:30 | Bethune Cookman v Miami Florida | L | 13-70 |
| NCAAF | 2021/11/20 20:30 | Florida A&M v Bethune Cookman | L | 46-21 |
| NCAAF | 2021/11/13 17:00 | Grambling State v Bethune Cookman | W | 14-31 |
| NCAAF | 2022/10/15 19:00 | Mississippi Valley State v Alabama State | L | 9-24 |
| NCAAF | 2022/10/08 23:00 | Alcorn State v Mississippi Valley State | L | 30-7 |
| NCAAF | 2022/10/01 22:00 | Mississippi Valley State v Florida A&M | L | 7-34 |
| NCAAF | 2022/09/24 18:00 | Mississippi Valley State v Jackson State | L | 7-49 |
| NCAAF | 2022/09/17 23:00 | Mississippi Valley State v Delta State | L | 17-28 |
| NCAAF | 2022/09/10 20:00 | Mississippi Valley State v Austin Peay | L | 0-41 |
| NCAAF | 2022/09/02 00:00 | Mississippi Valley State v Tarleton State | L | 13-29 |
| NCAAF | 2021/11/27 20:00 | Mississippi Valley State v Prairie View | W | 24-19 |