Stadium: O'Shaughnessy Stadium Round: 1
Home Manager: Glenn Caruso Away Manager: Dale Lindsey
| NCAAF | 2022/10/15 21:00 | Presbyterian v San Diego | W | 3-28 |
| NCAAF | 2022/10/08 18:00 | San Diego v Drake Bulldogs | W | 22-10 |
| NCAAF | 2022/09/24 17:00 | San Diego v Valparaiso | L | 21-28 |
| NCAAF | 2022/09/18 02:00 | San Diego v UC Davis | L | 13-43 |
| NCAAF | 2022/09/10 21:00 | San Diego v Cal Poly | L | 27-28 |
| NCAAF | 2022/09/04 01:00 | La Verne v San Diego | W | 0-58 |
| NCAAF | 2021/11/20 18:00 | San Diego v Stetson Hatters | W | 41-16 |
| NCAAF | 2021/11/06 20:00 | Morehead State v San Diego | W | 3-10 |
| NCAAF | 2022/10/22 17:00 | St. Thomas (MN) v Presbyterian | W | 46-17 |
| NCAAF | 2022/10/15 18:00 | Drake Bulldogs v St. Thomas (MN) | W | 14-26 |
| NCAAF | 2022/10/08 18:00 | Davidson Wildcats v St. Thomas (MN) | W | 16-27 |
| NCAAF | 2022/10/01 16:00 | St. Thomas (MN) v Marist | W | 38-24 |
| NCAAF | 2022/09/24 18:00 | St. Thomas (MN) v Lincoln Oaklanders | W | 43-6 |
| NCAAF | 2022/09/10 18:00 | St. Thomas (MN) v Michigan Technological University Huskies | W | 32-6 |
| NCAAF | 2022/09/02 00:00 | St. Thomas (MN) v Southern Utah | L | 13-44 |
| NCAAF | 2021/11/20 19:00 | Presbyterian v St. Thomas (MN) | W | 15-54 |