Stadium: Jayne Stadium Round: 1
Home Manager: Rob Tenyer Away Manager: Dale Lindsey
| NCAAF | 2021/11/06 20:00 | Morehead State v San Diego | W | 3-10 |
| NCAAF | 2019/11/16 22:00 | Morehead State v San Diego | W | 20-52 |
| NCAAF | 2018/10/06 16:00 | San Diego v Morehead State | W | 51-34 |
| NCAAF | 2017/10/14 21:00 | San Diego v Morehead State | W | 56-27 |
| NCAAF | 2022/11/12 22:00 | Davidson Wildcats v San Diego | W | 14-31 |
| NCAAF | 2022/11/05 20:00 | Butler v San Diego | L | 26-23 |
| NCAAF | 2022/10/29 17:00 | San Diego v St. Thomas (MN) | L | 42-49 |
| NCAAF | 2022/10/15 21:00 | Presbyterian v San Diego | W | 3-28 |
| NCAAF | 2022/10/08 18:00 | San Diego v Drake Bulldogs | W | 22-10 |
| NCAAF | 2022/09/24 17:00 | San Diego v Valparaiso | L | 21-28 |
| NCAAF | 2022/09/18 02:00 | San Diego v UC Davis | L | 13-43 |
| NCAAF | 2022/09/10 21:00 | San Diego v Cal Poly | L | 27-28 |
| NCAAF | 2022/11/12 18:00 | Morehead State v Dayton | L | 27-49 |
| NCAAF | 2022/11/05 20:00 | Morehead State v Marist | L | 21-31 |
| NCAAF | 2022/10/29 16:00 | Morehead State v Butler | L | 20-56 |
| NCAAF | 2022/10/22 18:00 | Valparaiso v Morehead State | L | 40-35 |
| NCAAF | 2022/10/15 17:00 | Morehead State v Davidson Wildcats | L | 26-28 |
| NCAAF | 2022/10/01 17:00 | Presbyterian v Morehead State | W | 10-14 |
| NCAAF | 2022/09/24 17:00 | Morehead State v Stetson Hatters | L | 26-38 |
| NCAAF | 2022/09/17 22:00 | Morehead State v Kentucky Christian Knights | W | 49-14 |