Stadium: A.W. Mumford Stadium Round: 1
Home Manager: Eric Dooley Away Manager: Vincent Dancy
| NCAAF | 2022/11/05 22:00 | Southern v Florida A&M | L | 16-30 |
| NCAAF | 2022/10/29 18:00 | Southern v Jackson State | L | 0-35 |
| NCAAF | 2022/10/22 21:00 | Southern v Lynchburg Dragons | W | 51-7 |
| NCAAF | 2022/10/15 23:00 | Alcorn State v Southern | W | 17-21 |
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | W | 45-13 |
| NCAAF | 2022/10/01 23:00 | Arkansas Pine Bluff v Southern | W | 3-59 |
| NCAAF | 2022/09/17 21:00 | Southern v Texas Southern Tigers | L | 0-24 |
| NCAAF | 2022/09/10 23:30 | Southern v LSU | L | 17-65 |
| NCAAF | 2022/11/03 23:30 | Alabama v Mississippi Valley State | W | 20-30 |
| NCAAF | 2022/10/22 20:00 | Bethune Cookman v Mississippi Valley State | L | 45-35 |
| NCAAF | 2022/10/15 19:00 | Mississippi Valley State v Alabama State | L | 9-24 |
| NCAAF | 2022/10/08 23:00 | Alcorn State v Mississippi Valley State | L | 30-7 |
| NCAAF | 2022/10/01 22:00 | Mississippi Valley State v Florida A&M | L | 7-34 |
| NCAAF | 2022/09/24 18:00 | Mississippi Valley State v Jackson State | L | 7-49 |
| NCAAF | 2022/09/17 23:00 | Mississippi Valley State v Delta State | L | 17-28 |
| NCAAF | 2022/09/10 20:00 | Mississippi Valley State v Austin Peay | L | 0-41 |