Stadium: A.W. Mumford Stadium Round: 1
Home Manager: Eric Dooley Away Manager: Fred McNair
| NCAAF | 2021/10/30 23:00 | Alcorn State v Southern | L | 35-38 |
| NCAAF | 2019/12/07 21:00 | Southern v Alcorn State | W | 24-39 |
| NCAAF | 2019/10/26 19:00 | Southern v Alcorn State | W | 13-27 |
| NCAAF | 2018/12/01 21:30 | Southern v Alcorn State | W | 28-37 |
| NCAAF | 2018/09/29 23:00 | Alcorn State v Southern | W | 20-3 |
| NCAAF | 2017/09/23 23:00 | Alcorn State v Southern | W | 48-31 |
| NCAAF | 2022/10/08 23:00 | Alcorn State v Mississippi Valley State | W | 30-7 |
| NCAAF | 2022/09/24 23:00 | Arkansas Pine Bluff v Alcorn State | W | 21-38 |
| NCAAF | 2022/09/18 00:00 | Alcorn State v McNeese State | W | 30-19 |
| NCAAF | 2022/09/10 23:00 | Alcorn State v Tulane | L | 0-52 |
| NCAAF | 2022/09/03 23:00 | Stephen F. Austin v Alcorn State | L | 31-27 |
| NCAAF | 2021/11/20 19:00 | Alcorn State v Jackson State | L | 10-24 |
| NCAAF | 2021/11/13 20:00 | Prairie View v Alcorn State | W | 29-31 |
| NCAAF | 2021/11/06 16:00 | Alcorn State v Bethune Cookman | L | 31-35 |
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | W | 45-13 |
| NCAAF | 2022/10/01 23:00 | Arkansas Pine Bluff v Southern | W | 3-59 |
| NCAAF | 2022/09/17 21:00 | Southern v Texas Southern Tigers | L | 0-24 |
| NCAAF | 2022/09/10 23:30 | Southern v LSU | L | 17-65 |
| NCAAF | 2022/09/03 23:00 | Southern v Florida Memorial University Lions | W | 86-0 |
| NCAAF | 2021/11/27 22:00 | Southern v Grambling State | L | 26-29 |
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | L | 21-17 |
| NCAAF | 2021/11/06 23:00 | Florida A&M v Southern | L | 29-17 |