Southern 0-24 Texas Southern 2022-09-17 21:00
Stadium: Globe Life Park Round: 1
Home Manager: Clarence McKinney Away Manager: Eric Dooley
Head to Head
| NCAAF | 2021/10/09 21:00 | Southern v Texas Southern Tigers | L | 31-35 |
| NCAAF | 2021/03/21 00:30 | Southern v Texas Southern Tigers | W | 51-23 |
| NCAAF | 2019/10/19 19:00 | Southern v Texas Southern Tigers | W | 28-21 |
| NCAAF | 2018/10/20 19:00 | Texas Southern Tigers v Southern | W | 7-21 |
| NCAAF | 2017/11/11 23:00 | Texas Southern Tigers v Southern | W | 7-33 |
Home History
| NCAAF | 2022/09/10 23:30 | Southern v LSU | L | 17-65 |
| NCAAF | 2022/09/03 23:00 | Southern v Florida Memorial University Lions | W | 86-0 |
| NCAAF | 2021/11/27 22:00 | Southern v Grambling State | L | 26-29 |
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | L | 21-17 |
| NCAAF | 2021/11/06 23:00 | Florida A&M v Southern | L | 29-17 |
| NCAAF | 2021/10/30 23:00 | Alcorn State v Southern | W | 35-38 |
| NCAAF | 2021/10/23 23:00 | Prairie View v Southern | L | 48-21 |
| NCAAF | 2021/10/16 19:00 | Southern v Arkansas Pine Bluff | W | 34-7 |
Away History
| NCAAF | 2022/09/10 23:30 | Texas Southern Tigers v North Texas | L | 27-59 |
| NCAAF | 2022/09/03 23:00 | Texas Southern Tigers v Prairie View | L | 23-40 |
| NCAAF | 2021/11/20 20:00 | Texas Southern Tigers v Alabama State | L | 21-24 |
| NCAAF | 2021/11/13 20:00 | Alabama v Texas Southern Tigers | L | 52-49 |
| NCAAF | 2021/11/06 18:00 | Texas Southern Tigers v Jackson State | L | 21-41 |
| NCAAF | 2021/10/30 19:00 | Arkansas Pine Bluff v Texas Southern Tigers | W | 17-59 |
| NCAAF | 2021/10/24 00:00 | Alcorn State v Texas Southern Tigers | L | 44-27 |
| NCAAF | 2021/10/16 19:00 | Texas Southern Tigers v Grambling State | L | 20-34 |