Stadium: O'Shaughnessy Stadium Round: 1
Home Manager: Glenn Caruso Away Manager: Todd Stepsis
| NCAAF | 2022/10/08 18:00 | San Diego v Drake Bulldogs | L | 22-10 |
| NCAAF | 2022/10/01 17:00 | Drake Bulldogs v Dayton | L | 14-27 |
| NCAAF | 2022/09/24 18:00 | Marist v Drake Bulldogs | L | 30-25 |
| NCAAF | 2022/09/17 19:00 | Drake Bulldogs v Idaho | L | 14-42 |
| NCAAF | 2022/09/10 18:00 | Drake Bulldogs v Missouri S&t Miners | L | 14-17 |
| NCAAF | 2022/09/03 19:30 | Drake Bulldogs v North Dakota State | L | 14-56 |
| NCAAF | 2021/11/20 18:00 | Drake Bulldogs v Davidson Wildcats | L | 14-45 |
| NCAAF | 2021/11/13 18:00 | St. Thomas (MN) v Drake Bulldogs | L | 21-14 |
| NCAAF | 2022/10/08 18:00 | Davidson Wildcats v St. Thomas (MN) | W | 16-27 |
| NCAAF | 2022/10/01 16:00 | St. Thomas (MN) v Marist | W | 38-24 |
| NCAAF | 2022/09/24 18:00 | St. Thomas (MN) v Lincoln Oaklanders | W | 43-6 |
| NCAAF | 2022/09/10 18:00 | St. Thomas (MN) v Michigan Technological University Huskies | W | 32-6 |
| NCAAF | 2022/09/02 00:00 | St. Thomas (MN) v Southern Utah | L | 13-44 |
| NCAAF | 2021/11/20 19:00 | Presbyterian v St. Thomas (MN) | W | 15-54 |
| NCAAF | 2021/11/13 18:00 | St. Thomas (MN) v Drake Bulldogs | W | 21-14 |
| NCAAF | 2021/11/06 17:00 | St. Thomas (MN) v Davidson Wildcats | L | 15-42 |