Stadium: G.B. Hodge Center Round: 1
Home Manager: Kyle Perry Away Manager: Barclay Radebaugh
| NCAAB | 2017/11/15 00:00 | USC Upstate v Georgia Bulldogs | L | 65-74 |
| NCAAB | 2017/11/12 20:00 | USC Upstate v Allen | W | 85-66 |
| NCAAB | 2017/11/11 01:00 | Minnesota v USC Upstate | L | 92-77 |
| CIT | 2017/03/16 23:00 | Furman v USC Upstate | L | 79-57 |
| NCAAB | 2017/02/28 00:00 | Kennesaw State v USC Upstate | L | 80-78 |
| NCAAB | 2017/02/24 00:00 | NJIT v USC Upstate | L | 88-87 |
| NCAAB | 2017/02/18 19:00 | USC Upstate v Florida Gulf Coast | L | 89-97 |
| NCAAB | 2017/02/17 00:00 | USC Upstate v Stetson | L | 72-83 |
| NCAAB | 2017/11/16 00:30 | Charleston Southern v Columbia International | W | 98-58 |
| NCAAB | 2017/11/12 21:00 | NC State v Charleston Southern | L | 78-56 |
| NCAAB | 2017/11/11 00:00 | Davidson v Charleston Southern | L | 110-62 |
| NCAAB | 2017/03/03 00:00 | Charleston Southern v Winthrop | L | 78-92 |
| NCAAB | 2017/03/01 00:00 | Longwood v Charleston Southern | W | 74-79 |
| NCAAB | 2017/02/25 19:00 | Longwood v Charleston Southern | W | 78-86 |
| NCAAB | 2017/02/23 23:30 | Charleston Southern v Winthrop | L | 72-86 |
| NCAAB | 2017/02/18 22:30 | Charleston Southern v High Point | W | 76-75 |