[7] Stefanos Tsitsipas 7-6,5-7,6-3 John Isner [50] 2022-08-19 19:00
Stadium: Center Court Round: 27 Ground: Hardcourt outdoor
Head to Head
| French Open | 2021/06/04 19:00 | Stefanos Tsitsipas v John Isner | 5-7,6-3,7-6,6-1 |
| ATP Acapulco | 2021/03/18 04:00 | Stefanos Tsitsipas v John Isner | 6-3,6-2 |
| ATP New York | 2020/08/25 21:30 | John Isner v Stefanos Tsitsipas | 6-7,6-7 |
| ATP Beijing | 2019/10/04 08:50 | John Isner v Stefanos Tsitsipas | 6-7,3-6 |
| Wimbledon | 2018/07/09 13:40 | John Isner v Stefanos Tsitsipas | 6-4,7-6,7-6 |
| ATP Shanghai | 2017/10/11 12:20 | Stefanos Tsitsipas v John Isner | 6-7,6-7 |
Home History
| ATP Cincinnati | 2022/08/18 17:30 | Stefanos Tsitsipas v Diego Schwartzman | 6-3,6-3 |
| ATP Cincinnati | 2022/08/17 19:25 | Stefanos Tsitsipas v Filip Krajinovic | 6-3,6-4 |
| ATP Montreal | 2022/08/11 02:20 | Jack Draper v Stefanos Tsitsipas | 7-5,7-6 |
| Wimbledon | 2022/07/02 16:50 | Nick Kyrgios v Stefanos Tsitsipas | 6-7,6-4,6-3,7-6 |
| Wimbledon | 2022/06/30 12:00 | Jordan Thompson v Stefanos Tsitsipas | 2-6,3-6,5-7 |
| Wimbledon | 2022/06/28 16:10 | Alexander Ritschard v Stefanos Tsitsipas | 6-7,3-6,7-5,4-6 |
| ATP Mallorca | 2022/06/25 13:00 | Roberto Bautista-Agut v Stefanos Tsitsipas | 4-6,6-3,6-7 |
| ATP Mallorca | 2022/06/24 13:00 | Benjamin Bonzi v Stefanos Tsitsipas | 4-6,4-6 |
Away History
| ATP Cincinnati | 2022/08/18 20:00 | Sebastian Korda v John Isner | 6-7,6-1,6-7 |
| ATP Cincinnati | 2022/08/17 16:35 | John Isner v Hubert Hurkacz | 7-6,6-7,6-2 |
| ATP Cincinnati | 2022/08/15 18:00 | Benjamin Bonzi v John Isner | 6-7,6-3,6-7 |
| ATP Atlanta | 2022/07/30 00:00 | Jenson Brooksby v John Isner | 3-6,6-1,6-4 |
| ATP Atlanta | 2022/07/29 00:40 | Ben Shelton v John Isner | 6-7,6-4,6-7 |
| ATP Newport | 2022/07/16 17:00 | Maxime Cressy v John Isner | 6-2,4-6,6-3 |
| ATP Newport | 2022/07/14 18:15 | Benjamin Bonzi v John Isner | 6-7,7-6,6-7 |
| ATP Newport | 2022/07/13 19:55 | Peter Gojowczyk v John Isner | 3-6,6-7 |