| Colombia Regional League | 2021/06/11 17:00 | Club Deportivo La Chalaca v Atletico Nacional Medellin Reserves | W | 1-0 |
| Colombia Regional League | 2022/07/26 15:30 | FC Leones Reserves v Club Deportivo La Chalaca | W | 3-4 |
| Colombia Regional League | 2022/07/20 19:28 | Club Deportivo La Chalaca v Real Santuario | W | 4-2 |
| Colombia Regional League | 2022/07/02 19:15 | Club Deportivo La Chalaca v Deportivo Alexis Garcia | L | 0-4 |
| Colombia Regional League | 2022/05/27 15:00 | Club Deportivo La Chalaca v Medellin City FC | W | 4-1 |
| Colombia Regional League | 2022/05/16 15:10 | Club Deportivo La Chalaca v Molino Viejo | W | 4-1 |
| Colombia Regional League | 2022/04/25 14:16 | Lula FC v Club Deportivo La Chalaca | L | 6-1 |
| Colombia Regional League | 2022/04/11 15:13 | Club Deportivo La Chalaca v Aguilas Doradas Reserves | D | 1-1 |
| Colombia Regional League | 2022/04/04 15:10 | Club Deportivo La Chalaca v Estudiantes de Medellin | W | 3-1 |
| Colombia Regional League | 2022/08/03 17:00 | Sellos Colombianos v Atletico Nacional Medellin Reserves | D | 2-2 |
| Colombia Regional League | 2022/07/03 21:24 | Estudiantes de Medellin v Atletico Nacional Medellin Reserves | W | 0-4 |
| Colombia Regional League | 2022/06/10 13:00 | Envigado FC Reserves v Atletico Nacional Medellin Reserves | L | 2-0 |
| Colombia Regional League | 2022/05/24 15:00 | FC Leones Reserves v Atletico Nacional Medellin Reserves | L | 2-1 |
| Colombia Regional League | 2022/05/10 17:13 | Universidad de Antioquia v Atletico Nacional Medellin Reserves | W | 0-1 |
| Colombia Regional League | 2022/04/23 16:00 | Independiente Sabaneta v Atletico Nacional Medellin Reserves | D | 0-0 |
| Colombia Regional League | 2022/03/22 17:14 | Talento y Vida v Atletico Nacional Medellin Reserves | W | 0-5 |
| Colombia Regional League | 2021/11/27 19:24 | Atletico Nacional Medellin Reserves v Deportivo Alexis Garcia | W | 2-0 |