Head to Head
| Premiership Rugby | 2022/04/03 14:00 | London Irish v Harlequins | W | 14-41 |
| Premiership Rugby Cup | 2022/03/18 19:45 | London Irish v Harlequins | L | 34-19 |
| Premiership Rugby | 2021/11/27 15:00 | Harlequins v London Irish | L | 19-22 |
| Premiership Rugby | 2021/04/24 11:30 | London Irish v Harlequins | W | 21-25 |
| Premiership Rugby | 2021/01/10 15:00 | Harlequins v London Irish | D | 27-27 |
| Premiership Rugby | 2020/09/09 18:45 | London Irish v Harlequins | W | 15-38 |
| Premiership Rugby | 2020/02/15 15:00 | Harlequins v London Irish | L | 15-29 |
| Premiership Rugby Cup | 2019/09/28 14:00 | London Irish v Harlequins | W | 18-21 |
Home History
| Premiership Rugby | 2022/09/17 14:00 | Harlequins v Saracens | L | 27-30 |
| Premiership Rugby | 2022/09/10 14:00 | Newcastle Falcons v Harlequins | W | 31-40 |
| Premiership Rugby | 2022/06/11 12:30 | Saracens v Harlequins | L | 34-17 |
| Premiership Rugby | 2022/06/04 14:00 | Exeter Chiefs v Harlequins | L | 47-38 |
| Premiership Rugby | 2022/05/21 14:00 | Harlequins v Gloucester | W | 28-24 |
| Premiership Rugby | 2022/04/29 18:45 | Northampton v Harlequins | L | 32-31 |
| Premiership Rugby | 2022/04/23 14:00 | Harlequins v Leicester | W | 26-20 |
| European Rugby Champions Cup | 2022/04/16 11:30 | Harlequins v Montpellier | W | 33-20 |
Away History
| Premiership Rugby | 2022/09/17 13:00 | Northampton v London Irish | L | 38-22 |
| Premiership Rugby | 2022/05/21 14:00 | Bath v London Irish | L | 27-24 |
| Premiership Rugby Cup | 2022/05/17 18:45 | London Irish v Worcester Warriors | D | 25-25 |
| European Rugby Challenge Cup | 2022/05/08 11:30 | Toulon v London Irish | L | 19-18 |
| Premiership Rugby | 2022/05/01 14:00 | London Irish v Wasps | D | 42-42 |
| Premiership Rugby Cup | 2022/04/26 18:45 | London Irish v Leicester | W | 59-20 |
| Premiership Rugby | 2022/04/22 18:45 | Newcastle Falcons v London Irish | W | 14-42 |
| European Rugby Challenge Cup | 2022/04/15 16:30 | London Irish v Castres | W | 64-27 |