Stadium: Leckonby Stadium Round: 1
| NCAAF | 2021/11/13 17:00 | Buffalo State Bengals v St Lawrence Saints | W | 6-41 |
| NCAAF | 2021/11/06 17:00 | St Lawrence Saints v Rpi Engineers | L | 20-22 |
| NCAAF | 2021/10/30 17:00 | St Lawrence Saints v Rochester Yellowjackets | W | 34-10 |
| NCAAF | 2021/10/23 17:00 | Hobart Statesmen v St Lawrence Saints | L | 17-13 |
| NCAAF | 2021/10/16 17:00 | St Lawrence Saints v Ithaca Bombers | L | 0-17 |
| NCAAF | 2021/10/09 17:00 | Union Dutchmen v St Lawrence Saints | L | 37-7 |
| NCAAF | 2021/09/25 20:00 | St Lawrence Saints v Castleton Spartans | W | 55-3 |
| NCAAF | 2021/09/17 23:00 | Morrisville State Mustangs v St Lawrence Saints | W | 14-27 |
| NCAAF | 2021/11/20 17:00 | Endicott Gulls v Rpi Engineers | L | 14-20 |
| NCAAF | 2021/11/13 17:00 | Nichols Bison v Endicott Gulls | W | 3-37 |
| NCAAF | 2021/10/30 16:00 | Endicott Gulls v University of New England Noreasters | W | 19-17 |
| NCAAF | 2021/10/23 16:00 | Salve Regina Seahawks v Endicott Gulls | L | 21-14 |
| NCAAF | 2021/10/16 17:00 | Husson Eagles v Endicott Gulls | W | 17-24 |
| NCAAF | 2021/10/09 16:00 | Endicott Gulls v Western New England Golden Bears | W | 45-21 |
| NCAAF | 2021/10/02 16:00 | Endicott Gulls v Curry Colonels | W | 34-27 |
| NCAAF | 2021/09/25 18:00 | Norwich Cadets v Endicott Gulls | W | 21-30 |