Stadium: Bison Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | St Vincent Bearcats v Bethany Bison | L | 52-7 |
| NCAAF | 2021/11/06 17:00 | Waynesburg Yellow Jackets v Bethany Bison | L | 31-7 |
| NCAAF | 2021/10/30 17:00 | Bethany Bison v Westminster Titans | L | 6-42 |
| NCAAF | 2021/10/16 18:00 | Case Western Reserve Spartans v Bethany Bison | L | 53-0 |
| NCAAF | 2021/10/09 20:30 | Bethany Bison v Thiel Tomcats | W | 28-7 |
| NCAAF | 2021/10/02 17:00 | Bethany Bison v Carnegie Mellon Tartans | L | 7-47 |
| NCAAF | 2021/09/25 23:00 | Bethany Bison v Geneva Golden Tornadoes | L | 7-42 |
| NCAAF | 2021/09/18 22:00 | Washington And Jefferson Presidents v Bethany Bison | L | 28-3 |
| NCAAF | 2021/11/13 18:00 | Kenyon Lords v Hiram Terriers | L | 21-16 |
| NCAAF | 2021/11/06 17:00 | Hiram Terriers v Denison Big Red | L | 6-59 |
| NCAAF | 2021/10/30 16:00 | Wooster Scots v Hiram Terriers | L | 51-14 |
| NCAAF | 2021/10/23 17:00 | Hiram Terriers v Oberlin Yeomen | L | 28-31 |
| NCAAF | 2021/10/16 17:00 | Hiram Terriers v Allegheny Gators | L | 13-38 |
| NCAAF | 2021/10/09 17:00 | Ohio Wesleyan Battling Bishops v Hiram Terriers | L | 34-17 |
| NCAAF | 2021/10/02 17:00 | Depauw Tigers v Hiram Terriers | L | 57-7 |
| NCAAF | 2021/09/18 20:30 | Wittenberg Tigers v Hiram Terriers | L | 51-21 |