Stadium: General Charles C. Krulak Stadium Round: 1
| NCAAF | 2021/11/27 18:00 | Mary Hardin Baylor v Birmingham Southern Panthers | L | 42-7 |
| NCAAF | 2021/11/20 18:00 | Birmingham Southern Panthers v Huntingdon Hawks | W | 24-14 |
| NCAAF | 2021/11/13 19:00 | Millsaps Majors v Birmingham Southern Panthers | W | 7-49 |
| NCAAF | 2021/11/06 17:00 | Birmingham Southern Panthers v Trinity Tigers | L | 27-28 |
| NCAAF | 2021/10/30 19:00 | Berry Vikings v Birmingham Southern Panthers | W | 3-21 |
| NCAAF | 2021/10/23 21:30 | Birmingham Southern Panthers v Rhodes Lynx | W | 41-6 |
| NCAAF | 2021/10/16 17:00 | Centre Colonels v Birmingham Southern Panthers | W | 21-28 |
| NCAAF | 2021/10/09 18:00 | Hendrix Warriors v Birmingham Southern Panthers | W | 6-43 |
| NCAAF | 2021/11/13 19:00 | Mcmurry Warhawks v Mary Hardin Baylor | L | 3-77 |
| NCAAF | 2021/11/06 18:00 | Belhaven Blazers v Mcmurry Warhawks | L | 35-20 |
| NCAAF | 2021/10/30 18:00 | Mcmurry Warhawks v Sul Ross State Lobos | L | 11-24 |
| NCAAF | 2021/10/23 18:00 | Texas Lutheran Bulldogs v Mcmurry Warhawks | L | 28-21 |
| NCAAF | 2021/10/16 18:00 | Mcmurry Warhawks v Austin Kangaroos | W | 48-13 |
| NCAAF | 2021/10/02 18:00 | Hardin Simmons Cowboys v Mcmurry Warhawks | L | 24-21 |
| NCAAF | 2021/09/25 21:00 | Mcmurry Warhawks v Southwestern Pirates | W | 41-31 |
| NCAAF | 2021/09/18 23:00 | East Texas Baptist Tigers v Mcmurry Warhawks | L | 24-15 |