Stadium: Don Drumm Stadium Round: 1
| NCAAF | 2021/11/13 18:30 | Marietta Pioneers v Mount Union | L | 7-37 |
| NCAAF | 2021/11/06 17:30 | Marietta Pioneers v Otterbein Cardinals | W | 56-7 |
| NCAAF | 2021/10/30 17:30 | Baldwin Wallace Yellow Jackets v Marietta Pioneers | L | 24-21 |
| NCAAF | 2021/10/23 17:30 | Marietta Pioneers v John Carroll Blue Streaks | L | 10-19 |
| NCAAF | 2021/10/16 19:00 | Wilmington Quakers v Marietta Pioneers | W | 7-35 |
| NCAAF | 2021/10/09 19:00 | Marietta Pioneers v Heidelberg Student Princes | L | 21-44 |
| NCAAF | 2021/10/02 17:30 | Ohio Northern Polar Bears v Marietta Pioneers | L | 34-33 |
| NCAAF | 2021/09/25 17:30 | Capital Crusaders v Marietta Pioneers | W | 7-37 |
| NCAAF | 2021/11/13 19:00 | Dubuque Spartans v Loras Duhawks | W | 17-14 |
| NCAAF | 2021/11/06 18:00 | Central Dutch v Dubuque Spartans | L | 56-7 |
| NCAAF | 2021/10/30 18:00 | Dubuque Spartans v Coe Kohawks | L | 27-34 |
| NCAAF | 2021/10/23 18:00 | Wartburg Knights v Dubuque Spartans | L | 27-7 |
| NCAAF | 2021/10/16 19:00 | Dubuque Spartans v Simpson Storm | W | 41-28 |
| NCAAF | 2021/10/09 18:00 | Nebraska Wesleyan Prairie Wolves v Dubuque Spartans | W | 14-31 |
| NCAAF | 2021/10/02 18:00 | Dubuque Spartans v Buena Vista Beavers | W | 31-16 |
| NCAAF | 2021/09/18 18:00 | Luther Norse v Dubuque Spartans | W | 2-28 |