Stadium: Pete FioRito Stadium at McKinzie Field Round: 1
| NCAAF | 2021/11/06 18:00 | Eureka Red Devils v St Norbert Green Knights | L | 21-70 |
| NCAAF | 2021/10/30 18:00 | Eureka Red Devils v Lakeland Muskies | L | 16-45 |
| NCAAF | 2021/10/23 23:00 | Wisconsin Lutheran Warriors v Eureka Red Devils | L | 68-41 |
| NCAAF | 2021/10/16 23:00 | Aurora Spartans v Eureka Red Devils | L | 49-7 |
| NCAAF | 2021/10/09 18:00 | Eureka Red Devils v Concordia Wisconsin Falcons | L | 32-41 |
| NCAAF | 2021/10/02 21:00 | Eureka Red Devils v Concordia Chicago Cougars | W | 38-13 |
| NCAAF | 2021/09/25 18:00 | Benedictine Eagles v Eureka Red Devils | L | 49-29 |
| NCAAF | 2021/09/18 18:00 | Rockford Regents v Eureka Red Devils | W | 57-58 |
| NCAAF | 2021/11/13 19:00 | Nebraska Wesleyan Prairie Wolves v Coe Kohawks | L | 21-53 |
| NCAAF | 2021/11/06 18:00 | Wartburg Knights v Nebraska Wesleyan Prairie Wolves | L | 50-14 |
| NCAAF | 2021/10/30 18:00 | Nebraska Wesleyan Prairie Wolves v Simpson Storm | W | 44-14 |
| NCAAF | 2021/10/16 18:00 | Buena Vista Beavers v Nebraska Wesleyan Prairie Wolves | L | 50-7 |
| NCAAF | 2021/10/09 18:00 | Nebraska Wesleyan Prairie Wolves v Dubuque Spartans | L | 14-31 |
| NCAAF | 2021/10/02 18:00 | Luther Norse v Nebraska Wesleyan Prairie Wolves | W | 21-28 |
| NCAAF | 2021/09/25 18:00 | Nebraska Wesleyan Prairie Wolves v Loras Duhawks | L | 30-31 |
| NCAAF | 2021/09/18 18:00 | Central Dutch v Nebraska Wesleyan Prairie Wolves | L | 37-7 |