Stadium: Lewis Field Stadium Round: 1
| NCAAF | 2021/09/10 00:00 | Missouri Western Griffons v Fort Hays State University Tigers | L | 38-31 |
| NCAAF | 2019/09/13 00:00 | Fort Hays State University Tigers v Missouri Western Griffons | L | 17-28 |
| NCAAF | 2018/09/07 00:00 | Missouri Western Griffons v Fort Hays State University Tigers | L | 23-13 |
| NCAAF | 2022/09/02 00:00 | NW Missouri State v Fort Hays State University Tigers | L | 33-19 |
| NCAAF | 2021/11/13 19:00 | Fort Hays State University Tigers v Pittsburgh State Gorillas | L | 24-34 |
| NCAAF | 2021/10/30 18:00 | Fort Hays State University Tigers v Emporia State | L | 12-15 |
| NCAAF | 2021/10/23 18:30 | Central Missouri Mules v Fort Hays State University Tigers | W | 17-21 |
| NCAAF | 2021/10/17 00:00 | Fort Hays State University Tigers v Central Oklahoma | L | 14-24 |
| NCAAF | 2021/10/09 18:00 | Washburn Ichabods Football v Fort Hays State University Tigers | L | 23-20 |
| NCAAF | 2021/10/03 00:00 | Fort Hays State University Tigers v Nebraska Kearney | W | 42-35 |
| NCAAF | 2021/09/25 19:00 | Missouri Southern Lions v Fort Hays State University Tigers | W | 21-42 |
| NCAAF | 2022/09/02 00:00 | Missouri Western Griffons v Central Oklahoma | W | 35-0 |
| NCAAF | 2021/11/13 17:00 | Blue Tigers v Missouri Western Griffons | W | 12-41 |
| NCAAF | 2021/11/06 18:00 | Missouri Western Griffons v Central Missouri Mules | W | 59-28 |
| NCAAF | 2021/10/30 19:00 | Missouri Southern Lions v Missouri Western Griffons | W | 28-45 |
| NCAAF | 2021/10/23 21:00 | Missouri Western Griffons v Pittsburgh State Gorillas | L | 14-34 |
| NCAAF | 2021/10/16 21:00 | Missouri Western Griffons v Northeastern State Riverhawks | W | 57-24 |
| NCAAF | 2021/10/09 19:00 | Nebraska Kearney v Missouri Western Griffons | L | 35-14 |
| NCAAF | 2021/10/02 23:00 | Missouri Western Griffons v NW Missouri State | L | 7-30 |