Stadium: DiSanto Field Round: 1
| NCAAF | 2021/11/13 18:00 | Carnegie Mellon Tartans v Case Western Reserve Spartans | L | 24-6 |
| NCAAF | 2021/11/06 17:00 | Case Western Reserve Spartans v Grove City Wolverines | W | 35-21 |
| NCAAF | 2021/10/30 17:00 | Thiel Tomcats v Case Western Reserve Spartans | W | 12-30 |
| NCAAF | 2021/10/23 17:30 | Case Western Reserve Spartans v Geneva Golden Tornadoes | W | 42-38 |
| NCAAF | 2021/10/16 18:00 | Case Western Reserve Spartans v Bethany Bison | W | 53-0 |
| NCAAF | 2021/10/02 17:00 | St Vincent Bearcats v Case Western Reserve Spartans | L | 42-40 |
| NCAAF | 2021/09/25 23:00 | Case Western Reserve Spartans v Washington And Jefferson Presidents | L | 14-37 |
| NCAAF | 2021/09/18 23:00 | Case Western Reserve Spartans v Westminster Titans | L | 12-34 |
| NCAAF | 2021/11/27 17:00 | Mount Union v Johns Hopkins Blue Jays | L | 45-35 |
| NCAAF | 2021/11/20 17:00 | Salisbury Sea Gulls v Johns Hopkins Blue Jays | W | 20-45 |
| NCAAF | 2021/11/13 17:00 | Mcdaniel Green Terror v Johns Hopkins Blue Jays | W | 7-48 |
| NCAAF | 2021/11/06 17:00 | Johns Hopkins Blue Jays v Dickinson Red Devils | W | 37-17 |
| NCAAF | 2021/10/30 17:00 | Johns Hopkins Blue Jays v Susquehanna Crusaders | W | 38-17 |
| NCAAF | 2021/10/23 16:00 | Gettysburg Bullets v Johns Hopkins Blue Jays | W | 0-50 |
| NCAAF | 2021/10/15 23:00 | Muhlenberg Mules v Johns Hopkins Blue Jays | L | 21-6 |
| NCAAF | 2021/10/02 17:00 | Johns Hopkins Blue Jays v Franklin And Marshall Diplomats | W | 66-10 |