Stadium: Hantz Stadium Round: 1
| NCAAF | 2021/11/13 18:00 | Northern Michigan Wildcats v Northwood Timberwolves | L | 34-26 |
| NCAAF | 2021/11/06 17:00 | Northwood Timberwolves v Michigan Technological University Huskies | L | 0-34 |
| NCAAF | 2021/10/30 22:00 | Wayne State Warriors Football v Northwood Timberwolves | L | 56-21 |
| NCAAF | 2021/10/23 17:00 | Northwood Timberwolves v Davenport Panthers | L | 14-21 |
| NCAAF | 2021/10/16 18:00 | Saginaw Valley State Cardinals v Northwood Timberwolves | L | 31-13 |
| NCAAF | 2021/10/09 23:00 | Grand Valley State v Northwood Timberwolves | L | 70-9 |
| NCAAF | 2021/10/02 17:00 | Northwood Timberwolves v Ferris State | L | 25-67 |
| NCAAF | 2021/09/25 17:00 | Northwood Timberwolves v Northern Michigan Wildcats | W | 37-20 |
| NCAAF | 2021/11/13 18:00 | Kentucky Wesleyan v Ashland Eagles | L | 0-17 |
| NCAAF | 2021/11/06 17:00 | Hillsdale Chargers v Kentucky Wesleyan | L | 31-12 |
| NCAAF | 2021/10/30 19:00 | Lake Erie v Kentucky Wesleyan | L | 38-28 |
| NCAAF | 2021/10/23 16:00 | Kentucky Wesleyan v Tiffin Dragons | L | 28-34 |
| NCAAF | 2021/10/16 17:00 | Walsh U. Cavaliers v Kentucky Wesleyan | W | 13-23 |
| NCAAF | 2021/10/09 17:00 | Findlay Oilers v Kentucky Wesleyan | L | 31-19 |
| NCAAF | 2021/10/02 17:00 | Kentucky Wesleyan v Ohio Dominican Panthers | L | 30-32 |
| NCAAF | 2021/09/25 16:00 | Kentucky Wesleyan v William Jewell College Cardinals | W | 41-21 |