Stadium: Alexandre Stadium Round: 1
| NCAAF | 2021/09/04 17:00 | John Carroll Blue Streaks v Washington And Jefferson Presidents | W | 14-21 |
| NCAAF | 2021/11/13 18:00 | Washington And Jefferson Presidents v Waynesburg Yellow Jackets | W | 55-0 |
| NCAAF | 2021/11/06 17:00 | Carnegie Mellon Tartans v Washington And Jefferson Presidents | L | 27-11 |
| NCAAF | 2021/10/30 17:00 | Grove City Wolverines v Washington And Jefferson Presidents | W | 24-28 |
| NCAAF | 2021/10/23 17:00 | Washington And Jefferson Presidents v Westminster Titans | L | 18-23 |
| NCAAF | 2021/10/09 18:00 | Washington And Jefferson Presidents v St Vincent Bearcats | W | 63-22 |
| NCAAF | 2021/10/02 19:00 | Geneva Golden Tornadoes v Washington And Jefferson Presidents | W | 20-24 |
| NCAAF | 2021/09/25 23:00 | Case Western Reserve Spartans v Washington And Jefferson Presidents | W | 14-37 |
| NCAAF | 2021/09/18 22:00 | Washington And Jefferson Presidents v Bethany Bison | W | 28-3 |
| NCAAF | 2021/11/13 18:00 | Baldwin Wallace Yellow Jackets v John Carroll Blue Streaks | W | 28-29 |
| NCAAF | 2021/11/06 17:30 | Heidelberg Student Princes v John Carroll Blue Streaks | L | 27-21 |
| NCAAF | 2021/10/30 19:00 | John Carroll Blue Streaks v Wilmington Quakers | W | 50-7 |
| NCAAF | 2021/10/23 17:30 | Marietta Pioneers v John Carroll Blue Streaks | W | 10-19 |
| NCAAF | 2021/10/16 18:00 | John Carroll Blue Streaks v Ohio Northern Polar Bears | W | 27-17 |
| NCAAF | 2021/10/09 17:30 | Capital Crusaders v John Carroll Blue Streaks | W | 7-38 |
| NCAAF | 2021/10/02 17:30 | John Carroll Blue Streaks v Muskingum Muskies | W | 29-7 |
| NCAAF | 2021/09/25 17:30 | John Carroll Blue Streaks v Mount Union | L | 14-28 |